Cytotoxic Activity Evaluation, DNA and Thioredoxin Reductase Enzyme Interaction Studies of Heterobimetallic Pt(II)-Au(I) Complexes as Potential Anticancer Agents

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Fereidoonnezhad Masood; Kalantari Foroogh

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Journal: Jundishapur Scientific Medical Journal Year:2019 | Volume:18 | Issue:5 Page(s): 519-532

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Title

Cytotoxic Activity Evaluation, DNA and Thioredoxin Reductase Enzyme Interaction Studies of Heterobimetallic Pt(II)-Au(I) Complexes as Potential Anticancer Agents

Author(s)

Fereidoonnezhad Masood | Kalantari Foroogh | Issue Writer Certificate

Keywords

Heterobimetallic platinum (II)–gold(I) complexesQ1

Molecular dockingQ1

Cytotoxic activityQ2

GenotoxicityQ1

Abstract

Background and Objective: Platinum-based chemotherapy drugs like cisplatin are widely used in the treatment of cancer. However, because of its high side effects, the use of these compounds is limited. All of today's efforts are to design new platinum drugs, as well as hybrid of gold and platinum, which have a similar profile with cisplatin but have less side effects and wide spectrum on different cancer types. Material and Method: In this study, the Cytotoxic activity of heterobimetallic Pt(II)-Au(I) complexes on the cancer cell lines such as cervix (Hela), colon (SW1116), breast (MDA-MB-231) as well as normal breast (MCF-12A) cell line was evaluated using MTT method. Molecular docking studies of these compounds with DNA and thioredoxin reductase (TrxR), as targets for platinum and gold compounds, were conducted using AutoDock 4. 2 software. Using the comet assay, Genotoxicity of the best cytotoxic compound was also evaluated. Results: In evaluating the Cytotoxic activity, 1b and 2b complexes exhibited greater cytotoxicity than cisplatin. All compounds exhibited lower toxicity than cisplatin on normal breast cell line (MCF-12A). The interaction of complexes with DNA and TrxR using Molecular docking showed their binding mode and binding site to these targets. The Genotoxicity effect of these compounds was also confirmed by the comet assay. Conclusion: The results showed that these complexes have the ability to play a more effective role in the treatment of cancer by further biological studies.

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APA: Copy

Fereidoonnezhad, Masood, & Kalantari, Foroogh. (2019). Cytotoxic Activity Evaluation, DNA and Thioredoxin Reductase Enzyme Interaction Studies of Heterobimetallic Pt(II)-Au(I) Complexes as Potential Anticancer Agents. JUNDISHAPUR SCIENTIFIC MEDICAL JOURNAL, 18(5 ), 519-532. SID. https://sid.ir/paper/365420/en

Vancouver: Copy

Fereidoonnezhad Masood, Kalantari Foroogh. Cytotoxic Activity Evaluation, DNA and Thioredoxin Reductase Enzyme Interaction Studies of Heterobimetallic Pt(II)-Au(I) Complexes as Potential Anticancer Agents. JUNDISHAPUR SCIENTIFIC MEDICAL JOURNAL[Internet]. 2019;18(5 ):519-532. Available from: https://sid.ir/paper/365420/en

IEEE: Copy

Masood Fereidoonnezhad, and Foroogh Kalantari, “Cytotoxic Activity Evaluation, DNA and Thioredoxin Reductase Enzyme Interaction Studies of Heterobimetallic Pt(II)-Au(I) Complexes as Potential Anticancer Agents,” JUNDISHAPUR SCIENTIFIC MEDICAL JOURNAL, vol. 18, no. 5 , pp. 519–532, 2019, [Online]. Available: https://sid.ir/paper/365420/en

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