Prevalence of Pathogenic Genes cagA and vacA of Helicobacter pylori Isolated in Patients with Digestive Disorders

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Heidari Khatoon; KABOOSI HAMI; Jamali Ailar; GHAEMI EZZAT ALLAH; Peyravii Ghadikolaii Fatemeh

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Journal: IRANIAN JOURNAL OF MEDICAL MICROBIOLOGY Year:2019 | Volume:13 | Issue:1 Page(s): 80-88

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Title

Prevalence of Pathogenic Genes cagA and vacA of Helicobacter pylori Isolated in Patients with Digestive Disorders

Author(s)

Keywords

Helicobacter pyloriQ1

cagAQ3

vacAQ1

Peptic UlcerQ1

PCRQ1

Abstract

Background and Aims: Helicobacter pylori is the main cause of various gastroduodenal diseases. It is estimated that app roximately, more than half of the adult population in developed countries and 90% of people in developing countries infected with H. pylori. H. pylori infection may be related to Genetic of virulence factors and environmental factors. The aim of this study was to assess of frequency cagA and vacA genes of H. pylori isolated from patients with Gastrointestinal Disorders. Materials and Methods: This cross-sectional descriptive study carried out on 120 patients with gastrointestinal diseases in Gorgan city in 2017. (40 patients of gastric cancer, 40 patients of Peptic Ulcer, 40 patients of without cancer and ulcer). After genomic DNA extraction PCR was carried out using specific H. pylori primers. Results: Overall, 120 H. pylori strains were isolated. The frequency of cagA was %67. 5 in gastric cancer, %60 in Peptic Ulcer and %45 in patiens without ulcer and gastric cancer. Also frequency of vacA gene was detected %55 in gastric cancer, %40 in Peptic Ulcer and %27. 5 in patiens without ulcer and gastric cancer. Conclusion: Based on our findings it seems that the cag A and vac A genes were virulence among H. pylori isolated from studied patients. The frequency of cagA and vacA genes H. pylori were than in gastric cancer and Peptic Ulcer patients.

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References

Prevalence of cagA, cagT, cagE, vacA and hrgA genes in Helicobacter pylori strains isolated from patients with gastric cancer in Karaj city, 2016

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APA: Copy

Heidari, Khatoon, KABOOSI, HAMI, Jamali, Ailar, GHAEMI, EZZAT ALLAH, & Peyravii Ghadikolaii, Fatemeh. (2019). Prevalence of Pathogenic Genes cagA and vacA of Helicobacter pylori Isolated in Patients with Digestive Disorders. IRANIAN JOURNAL OF MEDICAL MICROBIOLOGY, 13(1 ), 80-88. SID. https://sid.ir/paper/365986/en

Vancouver: Copy

Heidari Khatoon, KABOOSI HAMI, Jamali Ailar, GHAEMI EZZAT ALLAH, Peyravii Ghadikolaii Fatemeh. Prevalence of Pathogenic Genes cagA and vacA of Helicobacter pylori Isolated in Patients with Digestive Disorders. IRANIAN JOURNAL OF MEDICAL MICROBIOLOGY[Internet]. 2019;13(1 ):80-88. Available from: https://sid.ir/paper/365986/en

IEEE: Copy

Khatoon Heidari, HAMI KABOOSI, Ailar Jamali, EZZAT ALLAH GHAEMI, and Fatemeh Peyravii Ghadikolaii, “Prevalence of Pathogenic Genes cagA and vacA of Helicobacter pylori Isolated in Patients with Digestive Disorders,” IRANIAN JOURNAL OF MEDICAL MICROBIOLOGY, vol. 13, no. 1 , pp. 80–88, 2019, [Online]. Available: https://sid.ir/paper/365986/en

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