Association between ERCC2 c. 2251A>C polymorphism and risk of colorectal cancer in Iran population

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Baghbani Arani Fahimeh; SHIRKAVAND ATEFEH

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Journal: Razi Journal of Medical Sciences Year:2019 | Volume:26 | Issue:6 Page(s): 25-32

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Information Journal Paper

Title

Association between ERCC2 c. 2251A>C polymorphism and risk of colorectal cancer in Iran population

Author(s)

Baghbani Arani Fahimeh | SHIRKAVAND ATEFEH | Issue Writer Certificate

Keywords

PolymorphismQ2

DNA repairQ1

ERCC2Q1

Colorectal cancerQ1

Abstract

Background: The excision repair cross-complementing group 2 (ERCC2 ) is a Nucleotide Excision Repair (NER) gene. The ERCC2 c. 2251A>C Polymorphism is located in codon 751 of exon 23 which result in amino acid changes (Lys751Gln) in the ERCC2. This Polymorphism is associated with decreased DNA repair capacity cause to genetic instability and carcinogenesis. Thus, we examined the associations between ERCC2 c. 2251A>C Polymorphism and sporadic Colorectal cancer in Iranian population. Methods: In this case-control study, 291 incident sporadic Colorectal cancer cases and 140 controls were analyzed. ERCC2 Genotyping was done using a polymerase chain reaction restriction fragment length poly-morphism (PCR-RFLP). Results: Genotype frequency of c. 2251A>C in ERCC2 in patients and healthy groups was significantly different (p<0. 05). The results indicated that the mutant allele (C) can increased significantly risk of Colorectal cancer (OR: 1. 37; 95% CI: 1. 03-1. 83). Also, In ERCC2 genotypes, the CC genotype led to an increase in risk of Colorectal cancer (OR: 2. 37; 95% CI: 1. 03-5. 48). Conclusion: According to the Our results the ERCC2 c. 2251A>C Polymorphism involved in Colorectal cancer susceptibility in Iranian population.

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References

DNA Repair Gene XRCC1 and XPD Polymorphisms and Gastric Cancer Risk: A Case-Control Study Outcome from Kashmir, India

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APA: Copy

Baghbani Arani, Fahimeh, & SHIRKAVAND, ATEFEH. (2019). Association between ERCC2 c. 2251A>C polymorphism and risk of colorectal cancer in Iran population. RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES), 26(6 ), 25-32. SID. https://sid.ir/paper/366061/en

Vancouver: Copy

Baghbani Arani Fahimeh, SHIRKAVAND ATEFEH. Association between ERCC2 c. 2251A>C polymorphism and risk of colorectal cancer in Iran population. RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES)[Internet]. 2019;26(6 ):25-32. Available from: https://sid.ir/paper/366061/en

IEEE: Copy

Fahimeh Baghbani Arani, and ATEFEH SHIRKAVAND, “Association between ERCC2 c. 2251A>C polymorphism and risk of colorectal cancer in Iran population,” RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES), vol. 26, no. 6 , pp. 25–32, 2019, [Online]. Available: https://sid.ir/paper/366061/en

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