EVALUATION OF RELATIVE FREQUENCY OF SINGLE NUCLEOTIDE POLYMORPHISM G870A (RS9344) IN CYCLIND1 GENE IN COLORECTAL CANCER PATIENTS AND HEALTHY SUBJECTS OF ISFAHAN PROVINCE, IRAN

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RAHIMIRAD SHIMA; SALEHI RASOUL; SAFFAR BEHNAZ; NIAEE MOSTAFA

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Journal: Journal of Isfahan Medical School Year:2016 | Volume:34 | Issue:385 Page(s): 649-656

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Title

EVALUATION OF RELATIVE FREQUENCY OF SINGLE NUCLEOTIDE POLYMORPHISM G870A (RS9344) IN CYCLIND1 GENE IN COLORECTAL CANCER PATIENTS AND HEALTHY SUBJECTS OF ISFAHAN PROVINCE, IRAN

Author(s)

RAHIMIRAD SHIMA | SALEHI RASOUL | SAFFAR BEHNAZ | NIAEE MOSTAFA | Issue Writer Certificate

Keywords

COLORECTAL CANCERQ1

SINGLE NUCLEOTIDE POLYMORPHISMQ2

CYCLIN D1 GENEQ1

Abstract

Background: COLORECTAL CANCER (CRC) is one of the most common cancers in the world. High activity of CyclinD1 gene has been seen in the progress of this cancer. A common polymorphism (G870A) in exon 4 of CyclinD1 produces a variant transcript with longer half-life and may cause uncontrollable cellular growth thus contributing to cancer development. This study was performed to evaluate the frequency of CCND1 G870A polymorphism between CRC cases and controls.Methods: DNA samples from peripheral blood leukocytes of 50 patients with sporadic COLORECTAL CANCER and 50 healthy subjects were extracted. CCND1 G870A polymorphism was genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) in healthy subjects and patients. Statistical analysis was performed by chi-squared test via SPSS software.Findings: Relationship between CCND1 G870A polymorphism in allele frequencies between cases and controls were not observed (P=0.204). While the frequency of AA genotype was significantly higher in patients (P=0.040, 95% CI=1.13-5.54, OR=2.25).Conclusion: According to the significant association observed between certain genotypes of this locus (AA) with COLORECTAL CANCER, it can be used in the future as a good prognostic marker in CRC screening programs.

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APA: Copy

RAHIMIRAD, SHIMA, SALEHI, RASOUL, SAFFAR, BEHNAZ, & NIAEE, MOSTAFA. (2016). EVALUATION OF RELATIVE FREQUENCY OF SINGLE NUCLEOTIDE POLYMORPHISM G870A (RS9344) IN CYCLIND1 GENE IN COLORECTAL CANCER PATIENTS AND HEALTHY SUBJECTS OF ISFAHAN PROVINCE, IRAN. JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S), 34(385), 649-656. SID. https://sid.ir/paper/50400/en

Vancouver: Copy

RAHIMIRAD SHIMA, SALEHI RASOUL, SAFFAR BEHNAZ, NIAEE MOSTAFA. EVALUATION OF RELATIVE FREQUENCY OF SINGLE NUCLEOTIDE POLYMORPHISM G870A (RS9344) IN CYCLIND1 GENE IN COLORECTAL CANCER PATIENTS AND HEALTHY SUBJECTS OF ISFAHAN PROVINCE, IRAN. JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S)[Internet]. 2016;34(385):649-656. Available from: https://sid.ir/paper/50400/en

IEEE: Copy

SHIMA RAHIMIRAD, RASOUL SALEHI, BEHNAZ SAFFAR, and MOSTAFA NIAEE, “EVALUATION OF RELATIVE FREQUENCY OF SINGLE NUCLEOTIDE POLYMORPHISM G870A (RS9344) IN CYCLIND1 GENE IN COLORECTAL CANCER PATIENTS AND HEALTHY SUBJECTS OF ISFAHAN PROVINCE, IRAN,” JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S), vol. 34, no. 385, pp. 649–656, 2016, [Online]. Available: https://sid.ir/paper/50400/en

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