Evaluation of the Effect of Rosmarinic Acid in Induction of Neural Differentiation in Wharton’ s Jelly Stem Cells

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Salmanvandi Mohsen; KERMANI SHABNAM; ALIZADEH AKRAM

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Journal: Journal of Isfahan Medical School Year:2019 | Volume:37 | Issue:519 Page(s): 242-248

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Information Journal Paper

Title

Evaluation of the Effect of Rosmarinic Acid in Induction of Neural Differentiation in Wharton’ s Jelly Stem Cells

Author(s)

Salmanvandi Mohsen | KERMANI SHABNAM | ALIZADEH AKRAM | Issue Writer Certificate

Keywords

Cell differentiationQ2

Wharton's jelly cellsQ1

Rosmarinic acidQ1

Abstract

Background: Rosemarinic acid is a phenolic compound that has neuroprotective properties. It has beneficial effect in neurological diseases such as Parkinson's and Alzheimer's. Rosmarinic acid increases the expression of neurotrophic factors such as brain-derived neurotrophic factor (BDNF), which can contribute in neuronal differentiation of stem cells. Methods: After isolation and proliferation, Wharton’ s jelly stem cells were placed in inductive culture medium containing Rosmarinic acid. MTT assay was used to evaluate toxicity. After 4 days, induction of neuronal differentiation in Wharton’ s jelly stem cells was evaluated using real-time polymerase chain reaction (real-time PCR) via analyzing the expression of Nestin and β-Tubulin III genes. Findings: MTT assay showed was no significant difference in viability between cells cultured in culture medium with Rosmarinic acid and control group (P < 0. 05). Real-time PCR showed that adding Rosmarinic acid to culture medium increased the expression of Nestin and β-Tubulin III genes (P < 0. 05). Conclusion: Increasing the expression of β-Tubulin III and Nestin, when there is Rosmarinic acid, may indicate a greater induction of neuronal differentiation in Wharton’ s jelly stem cells. The results show that Rosmarinic acid induces the neuronal differentiation of Wharton’ s jelly stem cells.

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APA: Copy

Salmanvandi, Mohsen, KERMANI, SHABNAM, & ALIZADEH, AKRAM. (2019). Evaluation of the Effect of Rosmarinic Acid in Induction of Neural Differentiation in Wharton’ s Jelly Stem Cells. JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S), 37(519 ), 242-248. SID. https://sid.ir/paper/366503/en

Vancouver: Copy

Salmanvandi Mohsen, KERMANI SHABNAM, ALIZADEH AKRAM. Evaluation of the Effect of Rosmarinic Acid in Induction of Neural Differentiation in Wharton’ s Jelly Stem Cells. JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S)[Internet]. 2019;37(519 ):242-248. Available from: https://sid.ir/paper/366503/en

IEEE: Copy

Mohsen Salmanvandi, SHABNAM KERMANI, and AKRAM ALIZADEH, “Evaluation of the Effect of Rosmarinic Acid in Induction of Neural Differentiation in Wharton’ s Jelly Stem Cells,” JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S), vol. 37, no. 519 , pp. 242–248, 2019, [Online]. Available: https://sid.ir/paper/366503/en

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