IMMUNOHISTOCHEMICAL STUDY OF COX-2 IN MELANOCYTIC SKIN LESIONS

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KHODAEIANI EEFFAT; FAKHRJOU ASHRAF; GHAREAGHAJI ZARE ARMAGHAN; TALGHINI SHAHLA; AMIRNIA MEHDI

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Journal: Medical Journal of Tabriz University of Medical Sciences Year:2017 | Volume:39 | Issue:1 Page(s): 38-44

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Title

IMMUNOHISTOCHEMICAL STUDY OF COX-2 IN MELANOCYTIC SKIN LESIONS

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Keywords

CYCLOXYGENASE-2Q1

MALIGNANT MELANOMAQ2

BENIGN MELANOCYTIC LESIONQ1

IMMUNOHISTOCHEMISTRYQ2

Abstract

Background: cyclooxygenase-2 (cox-2) is involved in pathogenesis of various tumors and possibly malignant skin tumors including MALIGNANT MELANOMA; however, there is not enough information about cox-2 expression in BENIGN MELANOCYTIC LESIONs. In the present study we compared the expression levels of cox-2 in MALIGNANT MELANOMA and BENIGN MELANOCYTIC LESIONs. Methods: In this analytical study, 42 MALIGNANT MELANOMA from all 4 subtypes and 38 BENIGN MELANOCYTIC LESIONs including dysplastic nevus, Spitz nevus and atypical nevus were evaluated for cox-2 expression using IMMUNOHISTOCHEMISTRY staining and intensity of cell staining (quantitatively and qualitatively). Results: MALIGNANT MELANOMA compared to BENIGN MELANOCYTIC LESIONs had significantly higher levels of staining (p<0. 001), and much more intense coloration (p<0. 001) and higher overall staining score (p<0. 001). Regarding the cox-2 staining between MALIGNANT MELANOMA subtypes, all four subtypes mostly had staining intensity over 60%. Also in terms of quality, the most intense staining was in the ALM, and LM and NM had moderate staining intensity. With increasing depth of involvement, cox-2 staining increases. Intensity of cell staining was also higher in cases with tumor depth of 2-4 mm. Conclusion: The results indicate the effectiveness of cox-2 in differentiating between MALIGNANT MELANOMA and BENIGN MELANOCYTIC LESIONs. cox-2 expression correlated with the depth of invasion. Although cox-2 alone cannot be used to differentiate melanoma from benign lesions, it can be helpful in combination with other methods, in determining the prognosis and future targeted therapies.

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APA: Copy

KHODAEIANI, EEFFAT, FAKHRJOU, ASHRAF, GHAREAGHAJI ZARE, ARMAGHAN, TALGHINI, SHAHLA, & AMIRNIA, MEHDI. (2017). IMMUNOHISTOCHEMICAL STUDY OF COX-2 IN MELANOCYTIC SKIN LESIONS. MEDICAL JOURNAL OF TABRIZ UNIVERSITY OF MEDICAL SCIENCES, 39(1 ), 38-44. SID. https://sid.ir/paper/366837/en

Vancouver: Copy

KHODAEIANI EEFFAT, FAKHRJOU ASHRAF, GHAREAGHAJI ZARE ARMAGHAN, TALGHINI SHAHLA, AMIRNIA MEHDI. IMMUNOHISTOCHEMICAL STUDY OF COX-2 IN MELANOCYTIC SKIN LESIONS. MEDICAL JOURNAL OF TABRIZ UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2017;39(1 ):38-44. Available from: https://sid.ir/paper/366837/en

IEEE: Copy

EEFFAT KHODAEIANI, ASHRAF FAKHRJOU, ARMAGHAN GHAREAGHAJI ZARE, SHAHLA TALGHINI, and MEHDI AMIRNIA, “IMMUNOHISTOCHEMICAL STUDY OF COX-2 IN MELANOCYTIC SKIN LESIONS,” MEDICAL JOURNAL OF TABRIZ UNIVERSITY OF MEDICAL SCIENCES, vol. 39, no. 1 , pp. 38–44, 2017, [Online]. Available: https://sid.ir/paper/366837/en

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