IMMUNOHISTOCHEMICAL EXPRESSION OF CYCLOOXYGENASE-2 IN URINARY BLADDER TRANSITIONAL CELL CARCINOMAS

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MORADI TABRIZ HEDIEH; OLFATI GOLROKH; AHMADI ALI; NIKI FARZANEH

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Journal: Tehran University Medical Journal Year:2012 | Volume:70 | Issue:4 Page(s): 228-235

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Title

IMMUNOHISTOCHEMICAL EXPRESSION OF CYCLOOXYGENASE-2 IN URINARY BLADDER TRANSITIONAL CELL CARCINOMAS

Author(s)

MORADI TABRIZ HEDIEH | OLFATI GOLROKH | AHMADI ALI | NIKI FARZANEH | Issue Writer Certificate

Keywords

CYCLOOXYGENASE-2Q2

IMMUNOHISTOCHEMISTRYQ3

TRANSITIONAL CELL CARCINOMAQ2

URINARY BLADDERQ2

Abstract

Background: TRANSITIONAL CELL CARCINOMA (TCC) is the most common type of URINARY BLADDER cancer. CYCLOOXYGENASE-2 (COX-2), a key enzyme in prostaglandins biosynthesis, has been introduced as a new candidate for targeted therapy in this cancer.In this study, we investigated the expression of COX-2 in URINARY BLADDER TCCs and its relationship with clinicopathological parameters such as tumor grade and stage.Methods: This cross-sectional study was performed in the Pathology department of Sina Hospital in Tehran, Iran during 2006-2011. Pathology reports of patients with definite diagnosis of URINARY BLADDER TCCs who had undergone Transurethral Resection (TUR) were reviewed and 40 cases were selected. Subsequently, COX-2 expression was assessed immunohistochemically by the examination of paraffin embedded tissue blocks. Staining in more than 5% of tumor cells was considered as positive expression.Results: COX-2 was expressed in 52.5% of the patients. High-grade tumors revealed a higher (87.5%) COX-2 expression versus other grades of the lesions and there was a statistically significant difference in COX-2 expression between them (P<0.001).Patients’ age was also related to the expression of this marker (P=0.03). In contrast, this marker did not correlate with other characteristics including gender, lymphatic invasion or tumor stage. In addition, perineurial or vascular invasions were not detected in any of the patients.Conclusion: COX-2 expression was seen in more than half of our patients and it had a marked relation to tumor differentiation. Accordingly, this molecule may be a useful tumor marker in the assessment of URINARY BLADDER cancers.

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APA: Copy

MORADI TABRIZ, HEDIEH, OLFATI, GOLROKH, AHMADI, ALI, & NIKI, FARZANEH. (2012). IMMUNOHISTOCHEMICAL EXPRESSION OF CYCLOOXYGENASE-2 IN URINARY BLADDER TRANSITIONAL CELL CARCINOMAS. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), 70(4), 228-235. SID. https://sid.ir/paper/38200/en

Vancouver: Copy

MORADI TABRIZ HEDIEH, OLFATI GOLROKH, AHMADI ALI, NIKI FARZANEH. IMMUNOHISTOCHEMICAL EXPRESSION OF CYCLOOXYGENASE-2 IN URINARY BLADDER TRANSITIONAL CELL CARCINOMAS. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ)[Internet]. 2012;70(4):228-235. Available from: https://sid.ir/paper/38200/en

IEEE: Copy

HEDIEH MORADI TABRIZ, GOLROKH OLFATI, ALI AHMADI, and FARZANEH NIKI, “IMMUNOHISTOCHEMICAL EXPRESSION OF CYCLOOXYGENASE-2 IN URINARY BLADDER TRANSITIONAL CELL CARCINOMAS,” TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), vol. 70, no. 4, pp. 228–235, 2012, [Online]. Available: https://sid.ir/paper/38200/en

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