Investigating the synergistic effect of pomegranate (Punica granatum L. ) peel extract and quercetin on Calu-6 human lung carcinoma cells

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Osmani Shima; MOHSENI KOUCHESFAHANI HOMA; JALALI HANIEH

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Journal: Feyz Medical Sciences Journal Year:2020 | Volume:23 | Issue:6 Page(s): 596-604

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Title

Investigating the synergistic effect of pomegranate (Punica granatum L. ) peel extract and quercetin on Calu-6 human lung carcinoma cells

Author(s)

Osmani Shima | MOHSENI KOUCHESFAHANI HOMA | JALALI HANIEH | Issue Writer Certificate

Keywords

Lung cancerQ2

QuercetinQ1

Pomegranate peel extractQ1

ProliferationQ1

MigrationQ2

Abstract

Background: Lung cancer is one of the most common cancers. Herbal compounds have been considered for the treatment of cancer due to anticancer effects. Peel of Pomegranate (Punica granatum L. ) has antioxidant and anticancer properties due to its phenolic compounds. Quercetin is a herbal flavonoid that can inhibit the Proliferation of cancer cells. The present study compared the anti-proliferative effects of pomegranate’ s fruit peel extract and Quercetin on the calu-6 human lung carcinoma cell line and their co-effects in inhibiting the Proliferation and Migration of cancer cells. Material and Methods: Calu-6 cell line was purchased from Pasteur institute and cultured in RPMI1640 medium containing 10% FBS and 1% antibiotic. To determine the survival rate of t-cells, MTT assay was performed. Type of cell death was determined by flow cytometry, and scratch test was used to determine the Migration rate of the cells. Results: The results showed that pomegranate fruit peel extract and Quercetin inhibited the Proliferation of Lung cancer cells. Also, Quercetin and pomegranate extract induced apoptosis in calu-6 cells individually and simultaneously so that the level of expression of annexin-V in Quercetin and Pomegranate peel extract was 18. 20% and 15. 59%, respectively, and increased by 25. 51% during the co-treatment that difference was significant at P<0. 05 The results of the scratch test also indicated that Pomegranate peel extract and Quercetin inhibited metastatic activity in calu-6 cells. Conclusion: The results of this study showed that Quercetin and Pomegranate peel extract have anti-cancer effects and can be considered as a complementary medicine of Lung cancer.

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APA: Copy

Osmani, Shima, MOHSENI KOUCHESFAHANI, HOMA, & JALALI, HANIEH. (2020). Investigating the synergistic effect of pomegranate (Punica granatum L. ) peel extract and quercetin on Calu-6 human lung carcinoma cells. FEYZ, 23(6 ), 596-604. SID. https://sid.ir/paper/367350/en

Vancouver: Copy

Osmani Shima, MOHSENI KOUCHESFAHANI HOMA, JALALI HANIEH. Investigating the synergistic effect of pomegranate (Punica granatum L. ) peel extract and quercetin on Calu-6 human lung carcinoma cells. FEYZ[Internet]. 2020;23(6 ):596-604. Available from: https://sid.ir/paper/367350/en

IEEE: Copy

Shima Osmani, HOMA MOHSENI KOUCHESFAHANI, and HANIEH JALALI, “Investigating the synergistic effect of pomegranate (Punica granatum L. ) peel extract and quercetin on Calu-6 human lung carcinoma cells,” FEYZ, vol. 23, no. 6 , pp. 596–604, 2020, [Online]. Available: https://sid.ir/paper/367350/en

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