Comparison of the prevalence of HBV, HCV, HIV, EBV and CMV infections in patients with scleroderma and healthy population

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MOAYEDI JAVAD; Musavi Zahra; HASHEMPOUR TAYEBEH; Nazarinia Mohammad Ali; Dehghani Behzad; Hasanshahi Zahra

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Journal: Tehran University Medical Journal Year:2019 | Volume:77 | Issue:5 Page(s): 314-319

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Title

Comparison of the prevalence of HBV, HCV, HIV, EBV and CMV infections in patients with scleroderma and healthy population

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Keywords

cytomegalovirusQ1

Epstein-Barr virusQ3

sclerodermaQ1

viral infectionsQ2

Abstract

Background: scleroderma is a chronic systemic disorder that affects the connective tissues. It is characterized by several immune manifestations, inflammation, vascular damage, and fibrosis. Some of the viral infections with complex mechanisms are involved in the development and progression of many autoimmune diseases, such as scleroderma. The present study aimed to investigate the serological prevalence of hepatitis B virus (HBV), hepatitis C virus (HCV), human immunodeficiency virus (HIV), Epstein-Barr virus (EBV), and cytomegalovirus (CMV) infections in Iranian patients with scleroderma. Methods: In this descriptive study 65 patients with scleroderma and 65 healthy individuals who had no autoimmune diseases and matched for age and sex, from May 2017 to April 2018 at Shiraz HIV/AIDS Research Center, Shiraz University of Medical Sciences, Shiraz, Iran, were included. The serum of study participants were evaluated for cytomegalovirus specific immunoglobulin G (CMV-IgG), Epstein-Barr virus viral capsid antigen immunoglobulin G (EBV-VCA-IgG), hepatitis B surface antigen (HBsAg), hepatitis C virus antibody (HCVAb), and human immunodeficiency virus antibody (HIVAb) using commercially available the enzyme-linked immunosorbent assay (ELISA) kit. Results: CMV-IgG was diagnosed in serum of all patients with scleroderma, while 49 (98%) healthy subjects had positive results for this test. In addition, EBV-VCA-IgG was diagnosed in 58 (89. 2%) sclerodermic patients and 40 (80%) healthy subjects. The prevalence of CMV-IgG and EBV-VCA-IgG was not significantly different between patients and healthy subjects and had no significant relationship with age and sex. However, the titer of antibodies against CMV and EBV infections in the scleroderma group was higher than that in the control group (P<0. 0001, and P<0. 0001), respectively. The presence of HBsAg and HIVAb was not confirmed in any of the patients with scleroderma, but HCVAb was detected only in one patient. All of the individuals in control group were serologically negative for HBsAg, HCVAb, and HIVAb. Conclusion: Serological prevalence of HBV, HCV, HIV, EBV, and CMV infections in patients with scleroderma is similar to the healthy group.

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APA: Copy

MOAYEDI, JAVAD, Musavi, Zahra, HASHEMPOUR, TAYEBEH, Nazarinia, Mohammad Ali, Dehghani, Behzad, & Hasanshahi, Zahra. (2019). Comparison of the prevalence of HBV, HCV, HIV, EBV and CMV infections in patients with scleroderma and healthy population. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), 77(5 ), 314-319. SID. https://sid.ir/paper/368016/en

Vancouver: Copy

MOAYEDI JAVAD, Musavi Zahra, HASHEMPOUR TAYEBEH, Nazarinia Mohammad Ali, Dehghani Behzad, Hasanshahi Zahra. Comparison of the prevalence of HBV, HCV, HIV, EBV and CMV infections in patients with scleroderma and healthy population. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ)[Internet]. 2019;77(5 ):314-319. Available from: https://sid.ir/paper/368016/en

IEEE: Copy

JAVAD MOAYEDI, Zahra Musavi, TAYEBEH HASHEMPOUR, Mohammad Ali Nazarinia, Behzad Dehghani, and Zahra Hasanshahi, “Comparison of the prevalence of HBV, HCV, HIV, EBV and CMV infections in patients with scleroderma and healthy population,” TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), vol. 77, no. 5 , pp. 314–319, 2019, [Online]. Available: https://sid.ir/paper/368016/en

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