The N-acetylgalactosamine-transferase11 (GALNT11) activation in leukemia and the role of cyclophosphamide and cytarabine in expression of this enzyme

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

Amin Mozaffari Shahrooz; Bazzaz Dehkharghani Roya; RAMEZANI FATEMEH; SAMADI NASER

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Medical Journal of Tabriz University of Medical Sciences Year:2019 | Volume:41 | Issue:3 Page(s): 24-30

Download Full-Text

Persian Verion

View:

472

Download:

Cites:

Information Journal Paper

Title

The N-acetylgalactosamine-transferase11 (GALNT11) activation in leukemia and the role of cyclophosphamide and cytarabine in expression of this enzyme

Author(s)

Amin Mozaffari Shahrooz | Bazzaz Dehkharghani Roya | RAMEZANI FATEMEH | SAMADI NASER | Issue Writer Certificate

Keywords

CyclophosphamideQ2

CytarabineQ1

LeukemiaQ3

N-acetylgalactosamine-transferase11Q1

Abstract

Background: We investigated the activation of N-acetylgalactosamine-transferase11 (GALNT11) and the role of Cyclophosphamide and Cytarabine in expression of this enzyme in AML and CML patients. Methods: GALNT11 activity and expression levels were evaluated in human chronic myelogenous Leukemia cells (K562) and human acute monocytic Leukemia cells (THP1) after incubation with different concentrations of Cyclophosphamide (Cyclo) and Cytarabine (Cyta). Anti-proliferative effects of Cyclo and Cyta were examined by MTT assay. Real time-PCR and ELISA assays were applied to investigate the expression and activity of GALNT11, respectively. Results: The IC50 values for Cyclo were 34. 73± 0. 12 μ M for K562 and 36. 16± 0. 23 μ M for THP1 cells. These valuses for Cyta were also 0. 38± 0. 15 μ M for K562 and 0. 52± 0. 18 μ M for THP1 cells. Conclusion: The activation and expression of GALNT11 increased in acute and chronic Leukemia as glycosylation disorders. Also Cyclophosphamide and specially Cytarabine cause significant increase in activation and expression of GALNT11 which inhibits glycosylation and tumorogenesis dependent signaling pathway.

Cites

No record.

References

Inhibitor of ppGalNAc-T3-mediated O-glycosylation blocks cancer cell invasiveness and lowers FGF23 levels

Cite

APA: Copy

Amin Mozaffari, Shahrooz, Bazzaz Dehkharghani, Roya, & RAMEZANI, FATEMEH. (2019). The N-acetylgalactosamine-transferase11 (GALNT11) activation in leukemia and the role of cyclophosphamide and cytarabine in expression of this enzyme. MEDICAL JOURNAL OF TABRIZ UNIVERSITY OF MEDICAL SCIENCES, 41(3 ), 24-30. SID. https://sid.ir/paper/369003/en

Vancouver: Copy

Amin Mozaffari Shahrooz, Bazzaz Dehkharghani Roya, RAMEZANI FATEMEH. The N-acetylgalactosamine-transferase11 (GALNT11) activation in leukemia and the role of cyclophosphamide and cytarabine in expression of this enzyme. MEDICAL JOURNAL OF TABRIZ UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2019;41(3 ):24-30. Available from: https://sid.ir/paper/369003/en

IEEE: Copy

Shahrooz Amin Mozaffari, Roya Bazzaz Dehkharghani, and FATEMEH RAMEZANI, “The N-acetylgalactosamine-transferase11 (GALNT11) activation in leukemia and the role of cyclophosphamide and cytarabine in expression of this enzyme,” MEDICAL JOURNAL OF TABRIZ UNIVERSITY OF MEDICAL SCIENCES, vol. 41, no. 3 , pp. 24–30, 2019, [Online]. Available: https://sid.ir/paper/369003/en

Related Journal Papers