EFFECTS OF EIGHT WEEKS AEROBIC TRAINING ON LEVELS OF AMYLOID β42, NEPRILYSIN AND γ- SECRETASE IN THE HIPPOCAMPUS OF MALE RAT ALZHEIMER'S MODEL BY HOMOCYSTEINE INJECTION

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YAGHOUBI ALI; SAGHEBJOO MARZIYEH; FALLAH MOHAMMADI ZIA; HEDAYATI MEHDI; HAJIZADEH MOGHADDAM AKBAR

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Journal: Koomesh Year:2016 | Volume:17 | Issue:4 (60) Page(s): 996-1005

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Title

EFFECTS OF EIGHT WEEKS AEROBIC TRAINING ON LEVELS OF AMYLOID β42, NEPRILYSIN AND γ- SECRETASE IN THE HIPPOCAMPUS OF MALE RAT ALZHEIMER'S MODEL BY HOMOCYSTEINE INJECTION

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Keywords

EXERCISE THERAPYQ2

ALZHEIMER DISEASEQ2

NEPRILYSINQ1

HOMOCYSTEINEQ2

Abstract

Introduction: The aim of present study was to investigate the effects of eight weeks aerobic training on amyloid b42 (A b1-42), NEPRILYSIN and γ-secretase levels in the hippocampus of male rat Alzheimer's model by HOMOCYSTEINE injection.Materials and Methods: For this purpose, 50 male Wistar rats (12 weeks old) were divided into five groups, including: Alzheimer’s control, Alzheimer's training, healthy control, healthy training and sham. To induce Alzheimer's, HOMOCYSTEINE, with a concentration of 0.6M, was infused into the rat cerebroventriculum. To assess the memory impairment induced by HOMOCYSTEINE, the shuttle box test was used. Training groups, exercised using treadmill with 27m/min at 0o slope (75-80% VO2max, 60min/day, 5 days/week). Amyloid b42, NEPRILYSIN and g- secretase levels were measured using rat ELISA kit.Results: The results showed that Aβ1-42 levels in the hippocampus of Alzheimer's control group was significantly higher than healthy control and healthy training group (P=0.001). The level of g- secretase in Alzheimer's control group was significantly higher than healthy control, healthy training and sham groups (P=0.001). Likewise, levels of this factor in Alzheimer's training group were significantly lower than Alzheimer's control group (P=0.001). No significant differences were found between NEPRILYSIN levels in different groups (P=0.07). Mean level of A b1-42 showed a significant positive correlation with g- secretase level (r=0.54; P=0.001).Conclusion: Based on these results, it s likely that continuous physical training can markedly reduce Ab level in the hippocampus through reducing the level of g- secretase and would be warrant to be considered as a complementary therapy in Alzheimer's disease.

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References

EFFECTS OF INTERMITTENT AEROBIC TRAINING ON PASSIVE AVOIDANCE TEST (SHUTTLE BOX) AND STRESS MARKERS IN THE DORSAL HIPPOCAMPUS OFWISTAR RATS EXPOSED TO ADMINISTRATION OF HOMOCYSTEINE

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APA: Copy

YAGHOUBI, ALI, SAGHEBJOO, MARZIYEH, FALLAH MOHAMMADI, ZIA, HEDAYATI, MEHDI, & HAJIZADEH MOGHADDAM, AKBAR. (2016). EFFECTS OF EIGHT WEEKS AEROBIC TRAINING ON LEVELS OF AMYLOID β42, NEPRILYSIN AND γ- SECRETASE IN THE HIPPOCAMPUS OF MALE RAT ALZHEIMER'S MODEL BY HOMOCYSTEINE INJECTION. KOOMESH, 17(4 (60)), 996-1005. SID. https://sid.ir/paper/36909/en

Vancouver: Copy

YAGHOUBI ALI, SAGHEBJOO MARZIYEH, FALLAH MOHAMMADI ZIA, HEDAYATI MEHDI, HAJIZADEH MOGHADDAM AKBAR. EFFECTS OF EIGHT WEEKS AEROBIC TRAINING ON LEVELS OF AMYLOID β42, NEPRILYSIN AND γ- SECRETASE IN THE HIPPOCAMPUS OF MALE RAT ALZHEIMER'S MODEL BY HOMOCYSTEINE INJECTION. KOOMESH[Internet]. 2016;17(4 (60)):996-1005. Available from: https://sid.ir/paper/36909/en

IEEE: Copy

ALI YAGHOUBI, MARZIYEH SAGHEBJOO, ZIA FALLAH MOHAMMADI, MEHDI HEDAYATI, and AKBAR HAJIZADEH MOGHADDAM, “EFFECTS OF EIGHT WEEKS AEROBIC TRAINING ON LEVELS OF AMYLOID β42, NEPRILYSIN AND γ- SECRETASE IN THE HIPPOCAMPUS OF MALE RAT ALZHEIMER'S MODEL BY HOMOCYSTEINE INJECTION,” KOOMESH, vol. 17, no. 4 (60), pp. 996–1005, 2016, [Online]. Available: https://sid.ir/paper/36909/en

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