Protective effect of melatonin and Amphotericin B in affected rats with Aspergillosis

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NOWROZI HOSSEIN; KAZEMI ALI; Shokri Mahsa

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Journal: JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES Year:2019 | Volume:21 | Issue:1 (69) Page(s): 46-51

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Title

Protective effect of melatonin and Amphotericin B in affected rats with Aspergillosis

Author(s)

NOWROZI HOSSEIN | KAZEMI ALI | Shokri Mahsa | Issue Writer Certificate

Keywords

MelatoninQ2

Amphotericin BQ2

AspergillosisQ3

IL.6Q1

TNFαQ1

Abstract

Background and Objective: Fungal diseases are increasing in immunocompromised patients. One of the important fungal disseases is Aspergillosis. Few studies have been conducted on the effects of Melatonin on fungal diseases. This study was performed to determine the protective effect of Melatonin and Amphotericin B in Aspergillosis in rat model. Methods: This experimental study was done on 40 Wistar rat with weight ranging from 200 to 250 grams. Animals were allocted in five groups. The first group was positive control (immunocompromised condition with cyclophosphamide and inoclusion of Aspergillus spore). The second groupe was negative control (without drug and inoclusion of Aspergillus spore) and the third group was treated by Melatonin (200 μ g/kg). The forth group was treated by Amphotericin B and fifth group was treated by Melatonin plus Amphotericin B, IL. 6 and TNFα were measured in the first and tenth days after contamination. Results: The level of the IL. 6 and TNFα in three interventional treated groups significantly reduced in compared to positive control group in first and tenth days (P<0. 05). The level of the IL. 6 and TNFα in Melatonin plus Amphotericin B group significantly reduced in comparison with Amphotericin B and Melatonin treated groups in first and tenth days (P<0. 05). Conclusion: Melatonin with Amphotericin B increases immune competent system in rats affected with Aspergillosis.

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APA: Copy

NOWROZI, HOSSEIN, KAZEMI, ALI, & Shokri, Mahsa. (2019). Protective effect of melatonin and Amphotericin B in affected rats with Aspergillosis. JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES, 21(1 (69) ), 46-51. SID. https://sid.ir/paper/369578/en

Vancouver: Copy

NOWROZI HOSSEIN, KAZEMI ALI, Shokri Mahsa. Protective effect of melatonin and Amphotericin B in affected rats with Aspergillosis. JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2019;21(1 (69) ):46-51. Available from: https://sid.ir/paper/369578/en

IEEE: Copy

HOSSEIN NOWROZI, ALI KAZEMI, and Mahsa Shokri, “Protective effect of melatonin and Amphotericin B in affected rats with Aspergillosis,” JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES, vol. 21, no. 1 (69) , pp. 46–51, 2019, [Online]. Available: https://sid.ir/paper/369578/en

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