EFFECTS OF DIETARY CONJUGATED LINOLEIC ACID ON SERUM VISFATIN LEVEL AND TUMOR NUMBER AND SIZE IN RAT MODEL OF COLORECTAL CANCER

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KAMAL ZAHRA; AJAMI MARJAN; BEHESHTI NASRIN; ABDOLLAHI MORTEZA; DAVOODI SAYED HOSSEIN

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Journal: Koomesh Year:2016 | Volume:18 | Issue:1 (61) Page(s): 165-173

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Title

EFFECTS OF DIETARY CONJUGATED LINOLEIC ACID ON SERUM VISFATIN LEVEL AND TUMOR NUMBER AND SIZE IN RAT MODEL OF COLORECTAL CANCER

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Keywords

VISFATINQ1

CONJUGATED LINOLEIC ACIDQ2

COLORECTAL CANCERQ1

Abstract

Introduction: COLORECTAL CANCER is the third causes of cancer death in the world. Recent studies have shown that the serum levels of VISFATIN are increased during malignancies, suugesting a role for vistatin in pathogenegis of malignancies. It is suggested that CONJUGATED LINOLEIC ACID, (CLA) can reduce the serum levels of vistatin. The aim of this syudy was to study the effects of dietary CONJUGATED LINOLEIC ACID on serum VISFATIN level in rat model of COLORECTAL CANCER.Materials and Methods: Sixteen male Wistar rats, weighing 250-300 g were divided into two groups: control and experimental. Both groups were injected subcutaneously, with 1, 2- Dimethyl Hydrazine at a dose of 15 mg/kg of body weight, twice per week for 6 weeks. The control group and experimental groups were gavaged with water (2 ml/kg) and CLA (200 mg/kg), respectively, for the first 4 weeks of study. After 6 weeks, the rats were killed and their blood and colorectal tissues were collected in order to analyze serum VISFATIN, tumor number and tumor size respectively by ELISA method, tumor numbering and macroscopic analysing.Results: VISFATIN levels decreased dramatically in the experimental group than control group (P=0.001). Tumor number and tumor size increased considerably in the control group than experimental group (P=0.000). There was a positive correlation between VISFATIN levels with tumor number (r=0.701, p=0.001) and also between plasma VISFATIN with tumor number×tumor size (r=0.771, p=0.000).Conclusion: This study shows that dietary CLA by reducing serum VISFATIN can decrease the tumor number and tumor size in rat model of COLORECTAL CANCER. Thus, CLA suppresses colon carcinogenesis by a mechanim probably involving reduced serum VISFATIN.

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APA: Copy

KAMAL, ZAHRA, AJAMI, MARJAN, BEHESHTI, NASRIN, ABDOLLAHI, MORTEZA, & DAVOODI, SAYED HOSSEIN. (2016). EFFECTS OF DIETARY CONJUGATED LINOLEIC ACID ON SERUM VISFATIN LEVEL AND TUMOR NUMBER AND SIZE IN RAT MODEL OF COLORECTAL CANCER. KOOMESH, 18(1 (61)), 165-173. SID. https://sid.ir/paper/36986/en

Vancouver: Copy

KAMAL ZAHRA, AJAMI MARJAN, BEHESHTI NASRIN, ABDOLLAHI MORTEZA, DAVOODI SAYED HOSSEIN. EFFECTS OF DIETARY CONJUGATED LINOLEIC ACID ON SERUM VISFATIN LEVEL AND TUMOR NUMBER AND SIZE IN RAT MODEL OF COLORECTAL CANCER. KOOMESH[Internet]. 2016;18(1 (61)):165-173. Available from: https://sid.ir/paper/36986/en

IEEE: Copy

ZAHRA KAMAL, MARJAN AJAMI, NASRIN BEHESHTI, MORTEZA ABDOLLAHI, and SAYED HOSSEIN DAVOODI, “ EFFECTS OF DIETARY CONJUGATED LINOLEIC ACID ON SERUM VISFATIN LEVEL AND TUMOR NUMBER AND SIZE IN RAT MODEL OF COLORECTAL CANCER,” KOOMESH, vol. 18, no. 1 (61), pp. 165–173, 2016, [Online]. Available: https://sid.ir/paper/36986/en

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