Preparation and Study of Nano-Niosomes Containing Doxorubicin and Evaluation of its Toxicity on Acute Myeloblastic Leukemia Cell Line KG-1

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Bahrami Banan Fatemeh; SHEIKHHA MOHAMMAD HASAN; GHASEMI NASRIN; Majdi zadeh Mohammad; HAGHIRALSADAT BIBI FATEMEH

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Journal: Payavard Salamat Year:2018 | Volume:12 | Issue:4 Page(s): 309-323

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Title

Preparation and Study of Nano-Niosomes Containing Doxorubicin and Evaluation of its Toxicity on Acute Myeloblastic Leukemia Cell Line KG-1

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Keywords

NiosomeQ1

NeoplasmQ1

DoxorubicinQ1

Bone MarrowQ1

KG-1 Cell LineQ1

Abstract

Background and Aim: One of the effective strategies for targeting chemotherapy in the treatment of cancer is the use of lipid nano-carriers. In this study, an optimal formulation of niosomal drug containing Doxorubicin has been developed to better fight cancer cells. Material and Methods: Niosomal vesicles were prepared using phosphatidylcholine (22%), span60 (52/5%), cholesterol (22/5%) and DSPE-PEG2000 (5%) by thin-film method. Then Doxorubicin was loaded into the Niosomes. Their physico-chemical features were assayed using Zeta-Sizer, FTIR and SEM, and the amount of drug release was calculated at 37° C and 44° C. At the end, the toxicity of the nano drug carrier system was measured on the KG-1 Cell Line of the Bone Marrow cancer by MTT method. Results: Niosomes containing Doxorubicin have a size of 160/37± 2/65nm, the encapsulation efficiency of 94/18%, zeta potential of-58/11± 1/24 mV and polydispersity index (PDI) of 0/234± 0/02. The release of the drug is controlled in this nano-carrier and FTIR and SEM investigations showed that the drug and nano-carrier did not interact and their particles had a spherical structure. Also, cellular studies showed that drug toxicity was higher in encapsulated conditions compared to non-encapsulated conditions. Conclusion: The results of this study, meanwhile confirming the proper physicochemical characteristics of the system and being a slow-release system indicate that this nano-carrier anionic increases the toxicity of the drug for the KG-1 Cell Line of the Bone Marrow, thus, this niosomal nano-carrier can be a suitable carrier for drug delivery to cancer cells.

Cites

Designing and Characterizing Nano-carriers Containing Nepeta Persica Extract and Their Effect on Bone Cancer

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APA: Copy

Bahrami Banan, Fatemeh, SHEIKHHA, MOHAMMAD HASAN, GHASEMI, NASRIN, Majdi zadeh, Mohammad, & HAGHIRALSADAT, BIBI FATEMEH. (2018). Preparation and Study of Nano-Niosomes Containing Doxorubicin and Evaluation of its Toxicity on Acute Myeloblastic Leukemia Cell Line KG-1. PAYAVARD-SALAMAT, 12(4 ), 309-323. SID. https://sid.ir/paper/407353/en

Vancouver: Copy

Bahrami Banan Fatemeh, SHEIKHHA MOHAMMAD HASAN, GHASEMI NASRIN, Majdi zadeh Mohammad, HAGHIRALSADAT BIBI FATEMEH. Preparation and Study of Nano-Niosomes Containing Doxorubicin and Evaluation of its Toxicity on Acute Myeloblastic Leukemia Cell Line KG-1. PAYAVARD-SALAMAT[Internet]. 2018;12(4 ):309-323. Available from: https://sid.ir/paper/407353/en

IEEE: Copy

Fatemeh Bahrami Banan, MOHAMMAD HASAN SHEIKHHA, NASRIN GHASEMI, Mohammad Majdi zadeh, and BIBI FATEMEH HAGHIRALSADAT, “Preparation and Study of Nano-Niosomes Containing Doxorubicin and Evaluation of its Toxicity on Acute Myeloblastic Leukemia Cell Line KG-1,” PAYAVARD-SALAMAT, vol. 12, no. 4 , pp. 309–323, 2018, [Online]. Available: https://sid.ir/paper/407353/en

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