Investigating the role of JAK2 and STAT3 genes in lung cancer

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EMAMI MARYAM

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

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Journal: Research in Medicine Year:2019 | Volume:42 | Issue:4 Page(s): 209-214

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Information Journal Paper

Title

Investigating the role of JAK2 and STAT3 genes in lung cancer

Author(s)

EMAMI MARYAM | Issue Writer Certificate

Keywords

JAKQ1

STATQ1

MethylationQ1

PCRQ2

Real time PCRQ1

m RNAQ1

MSPQ1

Abstract

Backgroundm: Lung cancer is a disease that affects lung tissue cells. It is a common cancer in the world and is one of the most fatal cancers. Molecular variations of genes have a significant effect on the progression of the disease and blockage. These pathways can improve the treatment process. The purpose of the present study was to evaluate the modifications of the promoter Methylation of JAK2 / STAT3 signaling pathways and the level of expression of these genes at the level of mRNA, which has not been studied in lung cancer in Iran. Materials and Methods: In the current case control study, 75 samples of parathyroid cancer were collected and tumor margins were selected as control samples. Samples were collected from Imam Ali Hospital in Zahedan between April-December 1995. Initially, de-paraffinization was performed, and then DNA and RNA were extracted for further investigation Findings: The results of the study indicated that there is a risk of lung cancer between the STATus of the promoter’ s Methylation of both JAK2 and STAT3 genes [OR = 7. 15; p = 0. 001]. Conclusion: To the best of our knowledge, the present study is the first to show the association among the promoter of hyperMethylation of the JAK2 / STAT3 gene, the reduction of JAK2 expression, and an increased risk of lung cancer.

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APA: Copy

EMAMI, MARYAM. (2019). Investigating the role of JAK2 and STAT3 genes in lung cancer. PAJOUHESH DAR PEZESHKI, 42(4 ), 209-214. SID. https://sid.ir/paper/373249/en

Vancouver: Copy

EMAMI MARYAM. Investigating the role of JAK2 and STAT3 genes in lung cancer. PAJOUHESH DAR PEZESHKI[Internet]. 2019;42(4 ):209-214. Available from: https://sid.ir/paper/373249/en

IEEE: Copy

MARYAM EMAMI, “Investigating the role of JAK2 and STAT3 genes in lung cancer,” PAJOUHESH DAR PEZESHKI, vol. 42, no. 4 , pp. 209–214, 2019, [Online]. Available: https://sid.ir/paper/373249/en

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