EVALUATION OF GENETIC DAMAGE DUE TO CHEMOTHERAPY AND RADIOTHERAPY IN PATIENTS WITH ACUTE LYMPHOBLASTIC LEUKEMIA BY MICRONUCLEI ASSAY

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TAHERI MOHSEN; SHAHRABI S.; IZADYAR MINA

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Journal: Koomesh Year:2002 | Volume:3 | Issue:1-2 Page(s): 11-18

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Information Journal Paper

Title

EVALUATION OF GENETIC DAMAGE DUE TO CHEMOTHERAPY AND RADIOTHERAPY IN PATIENTS WITH ACUTE LYMPHOBLASTIC LEUKEMIA BY MICRONUCLEI ASSAY

Author(s)

TAHERI MOHSEN | SHAHRABI S. | | IZADYAR MINA | Issue Writer Certificate

Keywords

ACUTE LYMPHOBLASTIC LEUKEMIAQ3

CHEMOTHERAPYQ2

PATIENTSQ4

RADIOTHERAPYQ4

MICRONUCLEIQ4

Abstract

Introduction:Leukemia is a heterogenous group of neoplastic disorder, which derived from malignant transformation of hematopoietic progenitors. In most cases, leukemia is associated with cytogenetic disorder. In addition, cytogenetic disorders are induced by chemicals and radiation which are used as therapeutically regimens. MICRONUCLEI assay is one of the sensitive methods in evaluation of genetic and chromosomal aberration. In the present study, genetic alteration due to RADIOTHERAPY and CHEMOTHERAPY protocols in PATIENTS with ACUTE LYMPHOBLASTIC LEUKEMIA (ALL) are evaluated by MICRONUCLEI assay techniques. Materials and Methods:Total of 40 PATIENTS with ALL and 10 controls were used as sample subjects. According to treatment phases, PATIENTS were divided are into four groups as a without treatment, remission induction, consolidation and maintenance groups. Genetic alteration in these groups were evaluated by MICRONUCLEI assay techniques. Results:The frequency of MICRONUCLEI observed for each group was significantly higher than control group. Data also indicated that there were significant differences in the frequency of MICRONUCLEI among four groups. Conclusion:The findings indicate that RADIOTHERAPY and CHEMOTHERAPY in ALL PATIENTS mainly kills cells by induction of genetic loss (chromosomal aberration). Observation of genetic loss in erytrocytic cells can be considerd as a significant side of RADIOTHERAPY or CHEMOTHERAPY.

Cites

SURVEY OF CHROMOSOM ABERRATION INDUCED BY CHEMOTHERAPY AND RADIOTHERAPY PROTOCOLS IN LYMPHOCYTES OF THE PATIENT WITH AUTE LYMPHOCYTIC LEUKEMIA USING METAPHASE ANALYSIS METHOD

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APA: Copy

TAHERI, MOHSEN, SHAHRABI, S., IZADYAR, MINA. (2002). EVALUATION OF GENETIC DAMAGE DUE TO CHEMOTHERAPY AND RADIOTHERAPY IN PATIENTS WITH ACUTE LYMPHOBLASTIC LEUKEMIA BY MICRONUCLEI ASSAY . KOOMESH, 3(1-2), 11-18. SID. https://sid.ir/paper/37456/en

Vancouver: Copy

TAHERI MOHSEN, SHAHRABI S., IZADYAR MINA. EVALUATION OF GENETIC DAMAGE DUE TO CHEMOTHERAPY AND RADIOTHERAPY IN PATIENTS WITH ACUTE LYMPHOBLASTIC LEUKEMIA BY MICRONUCLEI ASSAY . KOOMESH[Internet]. 2002;3(1-2):11-18. Available from: https://sid.ir/paper/37456/en

IEEE: Copy

MOHSEN TAHERI, S. SHAHRABI, MINA IZADYAR, “EVALUATION OF GENETIC DAMAGE DUE TO CHEMOTHERAPY AND RADIOTHERAPY IN PATIENTS WITH ACUTE LYMPHOBLASTIC LEUKEMIA BY MICRONUCLEI ASSAY ,” KOOMESH, vol. 3, no. 1-2, pp. 11–18, 2002, [Online]. Available: https://sid.ir/paper/37456/en

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