EFFECT OF CROCIN ON SPERMATOGENESIS IN STREPTOZOTOCIN-INDUCED DIABETIC RATS

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

BAYATPOOR MOHAMMAD EHSAN; MIRZAEE SAEED; MOHAMMADI MOHAMMAD TAGHI

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES Year:2018 | Volume:28 | Issue:165 Page(s): 24-35

Download Full-Text

Persian Verion

View:

709

Download:

Cites:

Information Journal Paper

Title

EFFECT OF CROCIN ON SPERMATOGENESIS IN STREPTOZOTOCIN-INDUCED DIABETIC RATS

Author(s)

BAYATPOOR MOHAMMAD EHSAN | MIRZAEE SAEED | MOHAMMADI MOHAMMAD TAGHI | Issue Writer Certificate

Keywords

DIABETES MELLITUSQ3

CROCINQ1

SPERMATOGENESISQ2

HYPERGLYCEMIAQ2

STREPTOZOTOCINQ2

Abstract

Background and purpose: DIABETES MELLITUS affects male reproductive functions at multiplelevels such as SPERMATOGENESIS, steroidogenesis, and sexual behaviors. The pleotropic protective roles ofcrocin in different pathological states have been reported, so, this study aimed at examining the protectiveeffects of CROCIN on SPERMATOGENESIS in experimentally-induced diabetes in rats. Materials and methods: In an experimental study, 18 male Wistar rats were randomly dividedinto three groups; normal, diabetic, and CROCIN-treated diabetic groups. Diabetes was induced using i. v. injection of STREPTOZOTOCIN (40 mg/kg) and treatment group received i. p. injection of CROCIN (20mg/kg/day) for 60 days. At the end of the test, we studied blood glucose level, sperm count, and testisweight, and histopathological assessment was also performed. Results: Induction of diabetes enhanced blood glucose levels in diabetic group (229± 11mg/dL)whereas CROCIN significantly decreased blood glucose levels of treated diabetic group (118± 4mg/dL)compared with the diabetic group (P=0. 001). Sperm number decreased considerably in diabetic group(19. 4± 24 million/mL vs. 4. 4± 10 million/mL) but CROCIN significantly increased that (10. 3± 14million/mL), (P=0. 037). Diabetes also developed histopathological changes in seminiferous tubules andled to reduction of testis weight in diabetic rats, whereas CROCIN diminished these damages. Conclusion: Our findings revealed that CROCIN could protect male reproductive organ againstdiabetes and improve SPERMATOGENESIS in experimentally-induced diabetes in rat.

Cites

Effect of crocin on biochemical parameters, oxidative/antioxidative profiles, sperm characteristics and testicular histopathology in streptozotocin-induced diabetic rats

References

No record.

Cite

APA: Copy

BAYATPOOR, MOHAMMAD EHSAN, MIRZAEE, SAEED, & MOHAMMADI, MOHAMMAD TAGHI. (2018). EFFECT OF CROCIN ON SPERMATOGENESIS IN STREPTOZOTOCIN-INDUCED DIABETIC RATS. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, 28(165 ), 24-35. SID. https://sid.ir/paper/45352/en

Vancouver: Copy

BAYATPOOR MOHAMMAD EHSAN, MIRZAEE SAEED, MOHAMMADI MOHAMMAD TAGHI. EFFECT OF CROCIN ON SPERMATOGENESIS IN STREPTOZOTOCIN-INDUCED DIABETIC RATS. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2018;28(165 ):24-35. Available from: https://sid.ir/paper/45352/en

IEEE: Copy

MOHAMMAD EHSAN BAYATPOOR, SAEED MIRZAEE, and MOHAMMAD TAGHI MOHAMMADI, “EFFECT OF CROCIN ON SPERMATOGENESIS IN STREPTOZOTOCIN-INDUCED DIABETIC RATS,” JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, vol. 28, no. 165 , pp. 24–35, 2018, [Online]. Available: https://sid.ir/paper/45352/en

Related Journal Papers