INHIBITORY EFFECTS OF MENSTRUAL BLOOD STROMAL STEM CELLS ON GENERATION OF DENDRITIC CELLS FROM PERIPHERAL BLOOD MONOCYTES

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

BOZORGMEHR MAHMOOD; ZARNANI AMIR HASSAN; SHEIKHIAN ALI; SALEHNIA MOJDEH; JABBARI ARFAEE ALI; MOAZZENI SEYED MOHAMMAD

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Pathobiology Research Year:2012 | Volume:14 | Issue:4 Page(s): 23-36

Download Full-Text

Persian Verion

View:

2,282

Download:

Cites:

Information Journal Paper

Title

INHIBITORY EFFECTS OF MENSTRUAL BLOOD STROMAL STEM CELLS ON GENERATION OF DENDRITIC CELLS FROM PERIPHERAL BLOOD MONOCYTES

Author(s)

Keywords

MENSTRUAL BLOOD STEM CELLQ2

DENDRITIC CELLQ3

MONOCYTEQ3

MATURATIONQ3

SURFACE MARKERQ2

Abstract

Objective: Menstrual blood stromal stem cells (MBSCs) share some phenotypic and functional similarities with mesenchymal stem cells (MSCs). MSCs are shown to inhibit either the function or generation of different immune cells, including DENDRITIC CELLs (DCs). However, data regarding MBSCs’ potential effects on immune system cells are elusive. Here, we examine whether MBSCs affect the generation of human MONOCYTE-derived DCs. Methods: Menstrual blood samples were collected from apparently healthy women on the second day of their menstrual cycles. The adherent portions were subcultured to omit unwanted cells and obtain MBSCs. Magnetically-isolated peripheral blood MONOCYTEs were differentiated towards DCs through treatment with recombinant granulocyte MONOCYTE colony-stimulating factor (GM-CSF) and interleukin 4 (IL-4) in the presence or absence of MBSCs. After five days, MONOCYTE-derived DCs were analyzed for the expression of SURFACE MARKERs by flow cytometry. IL-6 level was determined in the co-culture supernatants.Results: Co-culture with MBSCs significantly down regulated the expression of DC marker (CD1a) and up regulated the expression of MONOCYTE marker (CD14) on MONOCYTE-derived DCs compared with the control group. IL-6 level was shown to be significantly higher in the supernatant of the MONOCYTE-MBSC co-culture.Conclusion: Collectively, this is the first study to show the inhibitory impacts of MBSCs on the generation of DCs. IL-6 could be viewd as a potential factor mediating this effect. Regarding the known advantages over MSCs, MBSCs could be considered as a promising future candidate for immunomodulatory purposes in the clinical setting.

Cites

A REVIEW ON CONTROVERSIES ABOUT THE ROLE OF IMMUNE AND INFLAMMATORY SYSTEMS IN IMPLANTATION PROCESS AND DURABILITY OF PREGNANCY

References

No record.

Cite

APA: Copy

BOZORGMEHR, MAHMOOD, ZARNANI, AMIR HASSAN, SHEIKHIAN, ALI, SALEHNIA, MOJDEH, JABBARI ARFAEE, ALI, & MOAZZENI, SEYED MOHAMMAD. (2012). INHIBITORY EFFECTS OF MENSTRUAL BLOOD STROMAL STEM CELLS ON GENERATION OF DENDRITIC CELLS FROM PERIPHERAL BLOOD MONOCYTES. PATHOBIOLOGY RESEARCH (MODARES JOURNAL OF MEDICAL SCIENCES), 14(4), 23-36. SID. https://sid.ir/paper/378507/en

Vancouver: Copy

BOZORGMEHR MAHMOOD, ZARNANI AMIR HASSAN, SHEIKHIAN ALI, SALEHNIA MOJDEH, JABBARI ARFAEE ALI, MOAZZENI SEYED MOHAMMAD. INHIBITORY EFFECTS OF MENSTRUAL BLOOD STROMAL STEM CELLS ON GENERATION OF DENDRITIC CELLS FROM PERIPHERAL BLOOD MONOCYTES. PATHOBIOLOGY RESEARCH (MODARES JOURNAL OF MEDICAL SCIENCES)[Internet]. 2012;14(4):23-36. Available from: https://sid.ir/paper/378507/en

IEEE: Copy

MAHMOOD BOZORGMEHR, AMIR HASSAN ZARNANI, ALI SHEIKHIAN, MOJDEH SALEHNIA, ALI JABBARI ARFAEE, and SEYED MOHAMMAD MOAZZENI, “INHIBITORY EFFECTS OF MENSTRUAL BLOOD STROMAL STEM CELLS ON GENERATION OF DENDRITIC CELLS FROM PERIPHERAL BLOOD MONOCYTES,” PATHOBIOLOGY RESEARCH (MODARES JOURNAL OF MEDICAL SCIENCES), vol. 14, no. 4, pp. 23–36, 2012, [Online]. Available: https://sid.ir/paper/378507/en

Related Journal Papers