A STUDY ON ASSOCIATION OF SNP-43 POLYMORPHISM IN CALPAIN-10 GENE WITH TYPE 2 DIABETES MELLITUS IN THE POPULATION OF EASTERN AZERBAIJAN PROVINCE

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BAHREINI F.; MOHADES ARDEBILI S.M.; FARAJNIA S.; GHAREH SOURAN J.; NABIPOUR I.; SOLTANIAN A.R.; ASKARZADEH A.L.

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Journal: IRANIAN SOUTH MEDICAL JOURNAL (ISMJ) Year:2012 | Volume:15 | Issue:1 Page(s): 35-42

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Title

A STUDY ON ASSOCIATION OF SNP-43 POLYMORPHISM IN CALPAIN-10 GENE WITH TYPE 2 DIABETES MELLITUS IN THE POPULATION OF EASTERN AZERBAIJAN PROVINCE

Author(s)

Keywords

CALPAIN10Q2

SNP43Q2

TYPE 2 DIABETESQ2

PCR-RFLPQ2

EASTERN AZERBAIJANQ3

Abstract

Background: Genome – wide analysis of genetic predisposition to TYPE 2 DIABETES mellitus in different populations have yielded variable results. CALPAIN10, a gene that encodes a non-lysosomal cysteine protease, has been recently proposed as a TYPE 2 DIABETES susceptibility genes in the non-insulin-dependent diabetes mellitus NIDDM1 region. Aim of the study is to evaluate the relation between SNP43 and type2 diabetes.Methods: A total of 102 diabetic subjects and 100 undiabetic controls enrolled in a case-control study in EASTERN AZERBAIJAN Azerbaijan Province. The polymerase chain reaction restriction fragment length polymorphism technique (PCR–RFLP) was applied. We use X2 test and logistic regression to analysis of data.Results: Genotypes distribution of CALPAIN10 gene in control group were 11 (11%), 86 (86%) and 3 (3%) with respected to A/G, G/G and A/A genotypes, respectively. In diabetic group genotypes distribution were 7 (6.9%), 95 (93.1%) and zero, respectively. The G allele frequency was significant difference in case and control groups.Conclusion: Since G allele is a risk factor to affect TYPE 2 DIABETES diseases; hence SNP43 of CALPAIN10 gene had significant association with TYPE 2 DIABETES in EASTERN AZERBAIJAN.

Cites

EFFECT OF ESTRADIOL VALERATE ON PANCREATIC BETA CELLS RESISTANCE IN DIABETIC FEMALE RATS BY STREPTOZOTOCIN

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APA: Copy

BAHREINI, F., MOHADES ARDEBILI, S.M., FARAJNIA, S., GHAREH SOURAN, J., NABIPOUR, I., SOLTANIAN, A.R., & ASKARZADEH, A.L.. (2012). A STUDY ON ASSOCIATION OF SNP-43 POLYMORPHISM IN CALPAIN-10 GENE WITH TYPE 2 DIABETES MELLITUS IN THE POPULATION OF EASTERN AZERBAIJAN PROVINCE. IRANIAN SOUTH MEDICAL JOURNAL (ISMJ), 15(1), 35-42. SID. https://sid.ir/paper/379651/en

Vancouver: Copy

BAHREINI F., MOHADES ARDEBILI S.M., FARAJNIA S., GHAREH SOURAN J., NABIPOUR I., SOLTANIAN A.R., ASKARZADEH A.L.. A STUDY ON ASSOCIATION OF SNP-43 POLYMORPHISM IN CALPAIN-10 GENE WITH TYPE 2 DIABETES MELLITUS IN THE POPULATION OF EASTERN AZERBAIJAN PROVINCE. IRANIAN SOUTH MEDICAL JOURNAL (ISMJ)[Internet]. 2012;15(1):35-42. Available from: https://sid.ir/paper/379651/en

IEEE: Copy

F. BAHREINI, S.M. MOHADES ARDEBILI, S. FARAJNIA, J. GHAREH SOURAN, I. NABIPOUR, A.R. SOLTANIAN, and A.L. ASKARZADEH, “A STUDY ON ASSOCIATION OF SNP-43 POLYMORPHISM IN CALPAIN-10 GENE WITH TYPE 2 DIABETES MELLITUS IN THE POPULATION OF EASTERN AZERBAIJAN PROVINCE,” IRANIAN SOUTH MEDICAL JOURNAL (ISMJ), vol. 15, no. 1, pp. 35–42, 2012, [Online]. Available: https://sid.ir/paper/379651/en

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