EFFECT OF POLYVINYLPYRROLIDONE ON THE AQUEOUS SOLUBILITY OF ACETAMINOPHEN AND INVESTIGATION OF THEIR INTERACTION MECHANISMS

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AFRASIABI GAREKANI H.; SADEGHI F.A.; GHAZI A.

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Journal: Iranian Journal of Basic Medical Sciences Year:2002 | Volume:5 | Issue:1 (13) Page(s): 4-9

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Information Journal Paper

Title

EFFECT OF POLYVINYLPYRROLIDONE ON THE AQUEOUS SOLUBILITY OF ACETAMINOPHEN AND INVESTIGATION OF THEIR INTERACTION MECHANISMS

Author(s)

AFRASIABI GAREKANI H. | SADEGHI F.A. | GHAZI A. | Issue Writer Certificate

Keywords

ACETAMINOPHENQ3

POLYVINYLPYRROLIDONEQ4

SOLUBILITYQ4

DIALYSIS EQUILIBRIUMQ4

COMPLEX FORMATIONQ4

INFERARED SPECTROSCOPYQ3

Abstract

It was shown that the aqueous SOLUBILITY of ACETAMINOPHEN in presence of PVP increased. The SOLUBILITY at 25°C increased from 14.3 mg ml-1 in absence of PVP, to 19.7mg ml-1 in presence of 4% w/v PVP, and to 26.7 mg ml-1 in presence of 8% w/v PVP. Dialysis studies indicated that there is a potential of binding between PVP and ACETAMINOPHEN in their aqueous solution. Dialysis studies also revealed that the nature of interaction between PVP and ACETAMINOPHEN is physical and reversible, and there was no strong binding between PVP and ACETAMINOPHEN in their solutions. Infrared spectroscopy of ACETAMINOPHEN /PVP co-precipitate indicated that the mechanism of interaction between PVP and ACETAMINOPHEN is via hydrogen bonding. Therefore the increase in SOLUBILITY of ACETAMINOPHEN in presence of PVP is attributed to its ability to form water soluble complex with PVP.

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APA: Copy

AFRASIABI GAREKANI, H., SADEGHI, F.A., & GHAZI, A.. (2002). EFFECT OF POLYVINYLPYRROLIDONE ON THE AQUEOUS SOLUBILITY OF ACETAMINOPHEN AND INVESTIGATION OF THEIR INTERACTION MECHANISMS. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 5(1 (13)), 4-9. SID. https://sid.ir/paper/380547/en

Vancouver: Copy

AFRASIABI GAREKANI H., SADEGHI F.A., GHAZI A.. EFFECT OF POLYVINYLPYRROLIDONE ON THE AQUEOUS SOLUBILITY OF ACETAMINOPHEN AND INVESTIGATION OF THEIR INTERACTION MECHANISMS. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2002;5(1 (13)):4-9. Available from: https://sid.ir/paper/380547/en

IEEE: Copy

H. AFRASIABI GAREKANI, F.A. SADEGHI, and A. GHAZI, “EFFECT OF POLYVINYLPYRROLIDONE ON THE AQUEOUS SOLUBILITY OF ACETAMINOPHEN AND INVESTIGATION OF THEIR INTERACTION MECHANISMS,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 5, no. 1 (13), pp. 4–9, 2002, [Online]. Available: https://sid.ir/paper/380547/en

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