BOTULINUM TOXIN TYPE A (DYSPORT) AS A PROPHYLACTIC TREATMENT OF MIGRAINE

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SICAROODI H.; FATHI D.; LOTFL J.

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Journal: Tehran University Medical Journal Year:2004 | Volume:62 | Issue:5 Page(s): 432-441

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Information Journal Paper

Title

BOTULINUM TOXIN TYPE A (DYSPORT) AS A PROPHYLACTIC TREATMENT OF MIGRAINE

Author(s)

SICAROODI H. | FATHI D. | LOTFL J. | Issue Writer Certificate

Keywords

MIGRAINE HEADACHEQ4

BOTULINUM TOXIN TYPE A (DYSPORT)Q4

PROPHYLAXISQ4

Abstract

Background: In this study the efficacy of botulinum toxin type A (Dysport) in the PROPHYLAXIS of MIGRAINE HEADACHE was compared with normal saline in this study.Materials and Methods: This is a double-blind placebo controlled study of 40 patients with history of MIGRAINE HEADACHE consistent with international headache society (IHS) criteria for migraine. The patients were randomized to receive a single injection of 125 units of dysport or the same volume of saline. Participants filled out daily diaries including: migraine frequency and severity, number of lost working days, nausea and vomiting due to attacks, attack duration, and number of oral or parenteral analgesics used to treat each attack during a I-month baseline period and 3-months post injection period of dysport or saline. Results: Demographic characteristics and baseline efficacy variables in both groups were similar. There was no statistically significant difference between two groups regarding primary efficacy variables including: frequency, mean severity, mean duration of attacks, nausea and vomiting associated with attacks and number of lost working days due to attacks. Changes from baseline in moderate to severe headaches (mean severity and mean duration >5) in third month after injection and changes from baseline in frequency of moderate to severe headaches requiring parenteral analgesics in third month after injection were significant (p =0.047 and p = 0.048 respectively).Conclusion: Botulinum toxin type A is effective in reducing the frequency of moderate to severe MIGRAINE HEADACHEs, and also the frequency of moderate to severe MIGRAINE HEADACHEs requiring parenteral analgesics. But the efficacy of botulinum toxin type A in prevention of all MIGRAINE HEADACHEs in general is not more than placebo.

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APA: Copy

SICAROODI, H., FATHI, D., & LOTFL, J.. (2004). BOTULINUM TOXIN TYPE A (DYSPORT) AS A PROPHYLACTIC TREATMENT OF MIGRAINE. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), 62(5), 432-441. SID. https://sid.ir/paper/38141/en

Vancouver: Copy

SICAROODI H., FATHI D., LOTFL J.. BOTULINUM TOXIN TYPE A (DYSPORT) AS A PROPHYLACTIC TREATMENT OF MIGRAINE. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ)[Internet]. 2004;62(5):432-441. Available from: https://sid.ir/paper/38141/en

IEEE: Copy

H. SICAROODI, D. FATHI, and J. LOTFL, “BOTULINUM TOXIN TYPE A (DYSPORT) AS A PROPHYLACTIC TREATMENT OF MIGRAINE,” TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), vol. 62, no. 5, pp. 432–441, 2004, [Online]. Available: https://sid.ir/paper/38141/en

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