Assessment of Correlation between Cell Cycle Regulatory Protein Cyclin D1 Expression and Prognostic Factors in Prostate Carcinoma

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Kheradmand Parvin; ESLAMI NARGES; khannejad Samin

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Journal: Jundishapur Scientific Medical Journal Year:2020 | Volume:19 | Issue:3 Page(s): 295-305

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Information Journal Paper

Title

Assessment of Correlation between Cell Cycle Regulatory Protein Cyclin D1 Expression and Prognostic Factors in Prostate Carcinoma

Author(s)

Kheradmand Parvin | ESLAMI NARGES | khannejad Samin | Issue Writer Certificate

Keywords

Prostate carcinomaQ2

Cyclin D1Q1

PrognosisQ3

Gleason scoreQ1

Abstract

Background and Objective: The effect of Cyclin D1 expression on prostate cancer has not yet been elucidated. The present study aimed to evaluate the relationship of the immunohistochemical expression of Cyclin D1 with tumor progression. Materials and Methods: In this descriptive cross-sectional study, tissue samples of patients referred to Imam Khomeini, Shahid Baqaei and Golestan hospitals of Ahvaz with confirmed diagnosis of prostate adenocarcinoma and benign prostatic hyperplasia were used. Clinical and demographic data of patients were extracted from hospital records. Immunohistochemical staining was performed using antiCyclin D1 monoclonal antibody. Results: In this study, 69 tissue samples from patients with prostate cancer were studied. Mean age of patients was 70 year. Immunohistochemical expression analysis of Cyclin D1 showed that only 6% of patients were negative and 32% had very strong expression. The high (plus-plus) expression of Cyclin D1 was significantly more frequent in high grade tumors (P=0. 02). Conclusion: Overall, the findings of this study indicate that the Cyclin D1 marker is broadly increased in prostate malignancy and its upregulation may be related to tumor grade based on Gleason score.

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References

KM-express: an integrated online patient survival and gene expression analysis tool for the identification and functional characterization of prognostic markers in breast and prostate cancers

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APA: Copy

Kheradmand, Parvin, ESLAMI, NARGES, & khannejad, Samin. (2020). Assessment of Correlation between Cell Cycle Regulatory Protein Cyclin D1 Expression and Prognostic Factors in Prostate Carcinoma. JUNDISHAPUR SCIENTIFIC MEDICAL JOURNAL, 19(3 ), 295-305. SID. https://sid.ir/paper/382173/en

Vancouver: Copy

Kheradmand Parvin, ESLAMI NARGES, khannejad Samin. Assessment of Correlation between Cell Cycle Regulatory Protein Cyclin D1 Expression and Prognostic Factors in Prostate Carcinoma. JUNDISHAPUR SCIENTIFIC MEDICAL JOURNAL[Internet]. 2020;19(3 ):295-305. Available from: https://sid.ir/paper/382173/en

IEEE: Copy

Parvin Kheradmand, NARGES ESLAMI, and Samin khannejad, “Assessment of Correlation between Cell Cycle Regulatory Protein Cyclin D1 Expression and Prognostic Factors in Prostate Carcinoma,” JUNDISHAPUR SCIENTIFIC MEDICAL JOURNAL, vol. 19, no. 3 , pp. 295–305, 2020, [Online]. Available: https://sid.ir/paper/382173/en

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