STEROIDAL ALKALOIDS ISOLATED FROM LEAF (OLEA EUROPAEA) DECREASED CEREBRAL ISCHEMIC-INDUCED INURY ON RATS

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ESMAEILI DEHAJ MANSOUR; DELFAN B.; MESHKAT ALSADAT M.H.; ALAEI H.A.; TAVAKOLI A.A.; SHAHSAVARI GH.R.; TARAHI M.J.

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Journal: Yafteh Year:2005 | Volume:7 | Issue:1 (24) Page(s): 3-10

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Title

STEROIDAL ALKALOIDS ISOLATED FROM LEAF (OLEA EUROPAEA) DECREASED CEREBRAL ISCHEMIC-INDUCED INURY ON RATS

Author(s)

Keywords

STEROIDAL ALKALOIDSQ4

CEREBRAL ISCHEMIA-REPERFUSIONQ2

ELECTROENCEPHALOGRAMQ3

LIPID PEROXIDASEQ4

Abstract

Background: The STEROIDAL ALKALOIDS incurring great interest because of their various pharmacological properties that isolated from various species. The aim of this investigation has been to studying of the effects of STEROIDAL ALKALOIDS isolated from olive leaf on cerebral ischemic-induced inury on rats.Materials and methods: In this experimental study, 48 male wistar rats divided to six groups of eight. Then CEREBRAL ISCHEMIA-REPERFUSION injury produced by 10 min bilateral occlusion of the common carotid and vertebral artery, followed by 5 day reperfusion.Findings: Intravenous setroidal alkaloids isolated from olive leaf (0.5, 1, 1.5 mg/kg) markdly reduced the stroke index, enhanced the recovery of EEG (Electroencephalogram) amplitude during reperfusion and decreased the concentration of cortex calcium and LPO (lipid peroxidase) in a dose dependent manner. However, no significant effects on water and sodium contents were observed.Conclusions: These results suggested that STEROIDAL ALKALOIDS exhibited protective effects on CEREBRAL ISCHEMIA-REPERFUSION injury in rats, and its mechanism might be related to reducing calcium accumulation and lipid peroxidation.

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APA: Copy

ESMAEILI DEHAJ, MANSOUR, DELFAN, B., MESHKAT ALSADAT, M.H., ALAEI, H.A., TARAHI, M.J., TAVAKOLI, A.A., & SHAHSAVARI, GH.R.. (2005). STEROIDAL ALKALOIDS ISOLATED FROM LEAF (OLEA EUROPAEA) DECREASED CEREBRAL ISCHEMIC-INDUCED INURY ON RATS. YAFTEH, 7(1 (24)), 3-10. SID. https://sid.ir/paper/382562/en

Vancouver: Copy

ESMAEILI DEHAJ MANSOUR, DELFAN B., MESHKAT ALSADAT M.H., ALAEI H.A., TARAHI M.J., TAVAKOLI A.A., SHAHSAVARI GH.R.. STEROIDAL ALKALOIDS ISOLATED FROM LEAF (OLEA EUROPAEA) DECREASED CEREBRAL ISCHEMIC-INDUCED INURY ON RATS. YAFTEH[Internet]. 2005;7(1 (24)):3-10. Available from: https://sid.ir/paper/382562/en

IEEE: Copy

MANSOUR ESMAEILI DEHAJ, B. DELFAN, M.H. MESHKAT ALSADAT, H.A. ALAEI, M.J. TARAHI, A.A. TAVAKOLI, and GH.R. SHAHSAVARI, “STEROIDAL ALKALOIDS ISOLATED FROM LEAF (OLEA EUROPAEA) DECREASED CEREBRAL ISCHEMIC-INDUCED INURY ON RATS,” YAFTEH, vol. 7, no. 1 (24), pp. 3–10, 2005, [Online]. Available: https://sid.ir/paper/382562/en

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