The effect of aerobic exercise training on hypoxia condition through PGC-1α angiogenesis signaling pathway in heart tissue of male westar rats

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

RAHIMIFARDIN SOHEILA; Siahkohian Marefat; KARIMI POURAN; BOLBOLI LOTFALI; Farhadi Hassan

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: MEDICAL JOURNAL OF TABRIZ UNIVERSITY OF MEDICAL SCIENCES Year:2020 | Volume:42 | Issue:3 Page(s): 263-272

Download Full-Text

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Verion

View:

376

Download:

Cites:

Information Journal Paper

Title

The effect of aerobic exercise training on hypoxia condition through PGC-1α angiogenesis signaling pathway in heart tissue of male westar rats

Author(s)

Keywords

HypoxiaQ2

AngiogenesisQ2

Aerobic trainingQ2

PGC-1αQ1

Abstract

Background: Despite the effect of PGC-1α; on biogenesis of mitochondria, the mechanism of its effect on cardiac Angiogenesis has not yet been studied. Therefore, the purpose of this study was to investigate the effect of Aerobic training and intermittent Hypoxia on the expression of PGC-1α; Angiogenesis-related proteins in the cardiac tissue. Methods: In an experimental study, Forty male Wistar rats weighing 220± 20 gr were randomly divided into four groups; control (C), Hypoxia (H), training (T), and Hypoxia + training (H+T) groups. Hypoxia group exposed to chronic intermittent Hypoxia (PiO2≈ 106 mmHg, simulated altitude ≈ 3400 m, 14% oxygen for 8 weeks). And exercise group ran on a treadmill for 8 weeks, 5 session/ week. Then, relative protein density of PGC-1α; , p-AMPK, ERRα , and VEGFA were measured with Western blot method. Results: The Aerobic training, intermittent Hypoxia, Aerobic training + Hypoxia significantly increased relative protein density of PGC-1α; , ERRα , and VEGFA compared to control group. Moreover, phosphorylation levels of AMPK showed an increase in all three groups compared to the control group. Conclusion: Although Hypoxia was an effective stimulator to induce the expression of PGC-1α; and VEGFA and aerobic exercise was a potent phosphorylation inducer of AMPK, their combination did not have a synergistic effect.

Cites

No record.

References

Cite

APA: Copy

RAHIMIFARDIN, SOHEILA, Siahkohian, Marefat, KARIMI, POURAN, BOLBOLI, LOTFALI, & Farhadi, Hassan. (2020). The effect of aerobic exercise training on hypoxia condition through PGC-1α angiogenesis signaling pathway in heart tissue of male westar rats. MEDICAL JOURNAL OF TABRIZ UNIVERSITY OF MEDICAL SCIENCES, 42(3 ), 263-272. SID. https://sid.ir/paper/382701/en

Vancouver: Copy

RAHIMIFARDIN SOHEILA, Siahkohian Marefat, KARIMI POURAN, BOLBOLI LOTFALI, Farhadi Hassan. The effect of aerobic exercise training on hypoxia condition through PGC-1α angiogenesis signaling pathway in heart tissue of male westar rats. MEDICAL JOURNAL OF TABRIZ UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2020;42(3 ):263-272. Available from: https://sid.ir/paper/382701/en

IEEE: Copy

SOHEILA RAHIMIFARDIN, Marefat Siahkohian, POURAN KARIMI, LOTFALI BOLBOLI, and Hassan Farhadi, “The effect of aerobic exercise training on hypoxia condition through PGC-1α angiogenesis signaling pathway in heart tissue of male westar rats,” MEDICAL JOURNAL OF TABRIZ UNIVERSITY OF MEDICAL SCIENCES, vol. 42, no. 3 , pp. 263–272, 2020, [Online]. Available: https://sid.ir/paper/382701/en

Related Journal Papers