Effect of 10 Weeks of High-Intensity Interval Training on Protein Levels of NF-kB and Expression of Atrogin-1 and MuRF-1 in Cardiomyocytes of Female Mice with Breast Cancer

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Yazdanshenas N.; PEERI M.; DELFAN M.

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Journal: Iranian Journal of Breast Diseases Year:2020 | Volume:13 | Issue:3 (50) Page(s): 63-71

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Title

Effect of 10 Weeks of High-Intensity Interval Training on Protein Levels of NF-kB and Expression of Atrogin-1 and MuRF-1 in Cardiomyocytes of Female Mice with Breast Cancer

Author(s)

Yazdanshenas N. | PEERI M. | DELFAN M. | Issue Writer Certificate

Keywords

HIITQ1

HeartQ1

Breast CancerQ2

NF-kBQ1

Atrogin-1Q1

MuRF-1Q1

Abstract

Introduction: Limiting cancer-induced cardiac atrophy is a highly important for improving the survival rates and quality of life in cancer patients. The purpose of this study was to evaluate the effect of 10 weeks of high-intensity interval training (HIIT) on cardiac muscle weight, NF-kB protein expression, and expression of Atrogin-1 and MuRF-1 genes in the Heart muscle of Breast Cancer– bearing female mice. Methods: In this experimental study, 12 BALB/c mice with induced Breast Cancer were divided into control and HIIT groups. The HIIT protocol consisted of six intervals of running at 85%-90% V̇ O2 peak, interspersed with 90 seconds of active rest, and five minutes of warm-up and cool-down. The left ventricular tissue was extracted 24 h following the last training session. Western blotting was used to measure protein levels of NF-kB, and quantitative real-time polymerase chain reaction was used to measure Atrogin-1 and MuRF-1 expression in the Heart tissue. Data were analyzed using an independent t test at a 0. 05 significance level. Results: The mean cardiac muscle weight in the HIIT group was greater than in the control group (P < 0. 001). A significant reduction in NF-kB protein levels (P = 0. 004) and expression of Atrogin-1 (P < 0. 001) and MuRF-1 (P < 0. 001) were observed in the HIIT group when compared with control group. Conclusion: Ten weeks of HIIT may inhibit NF-kB/Atrogin-1/MuRF-1 axis, leading to decreased atrophy and increased Heart weight in mice with Breast Cancer.

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APA: Copy

Yazdanshenas, N., PEERI, M., & DELFAN, M.. (2020). Effect of 10 Weeks of High-Intensity Interval Training on Protein Levels of NF-kB and Expression of Atrogin-1 and MuRF-1 in Cardiomyocytes of Female Mice with Breast Cancer. IRANIAN QUARTERLY JOURNAL OF BREAST DISEASE, 13(3 (50) ), 63-71. SID. https://sid.ir/paper/382843/en

Vancouver: Copy

Yazdanshenas N., PEERI M., DELFAN M.. Effect of 10 Weeks of High-Intensity Interval Training on Protein Levels of NF-kB and Expression of Atrogin-1 and MuRF-1 in Cardiomyocytes of Female Mice with Breast Cancer. IRANIAN QUARTERLY JOURNAL OF BREAST DISEASE[Internet]. 2020;13(3 (50) ):63-71. Available from: https://sid.ir/paper/382843/en

IEEE: Copy

N. Yazdanshenas, M. PEERI, and M. DELFAN, “Effect of 10 Weeks of High-Intensity Interval Training on Protein Levels of NF-kB and Expression of Atrogin-1 and MuRF-1 in Cardiomyocytes of Female Mice with Breast Cancer,” IRANIAN QUARTERLY JOURNAL OF BREAST DISEASE, vol. 13, no. 3 (50) , pp. 63–71, 2020, [Online]. Available: https://sid.ir/paper/382843/en

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