Inhibition of angiogenesis and improvement of the anti-angiogenic activity of paclitaxel by three insect sex pheromones in chicken chorioallantoic membrane

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Payambarpour Zeynab Sadat; HASSANPOUR EZATTI MAJID; ASKARIANZADEH ALIREZA

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Journal: MEDICAL JOURNAL OF TABRIZ UNIVERSITY OF MEDICAL SCIENCES Year:2020 | Volume:42 | Issue:3 Page(s): 245-253

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Title

Inhibition of angiogenesis and improvement of the anti-angiogenic activity of paclitaxel by three insect sex pheromones in chicken chorioallantoic membrane

Author(s)

Payambarpour Zeynab Sadat | HASSANPOUR EZATTI MAJID | ASKARIANZADEH ALIREZA | Issue Writer Certificate

Keywords

Angiogenesis InhibitorsQ1

Chorioallantoic MembraneQ1

InsectaQ1

PheromonesQ1

PaclitaxelQ1

DexamethasoneQ3

Abstract

Background: Insect sex Pheromones contain long chain polyunsaturated fatty acids. Some types of unsaturated fatty acids have been showed anticancer effects. Angiogenesis is considered as a fundamental process in cancer growth and metastasis. Angiogenesis inhibitory effect of three insect-free Pheromones alone and the incremental anti-angiogenic effect of each of them with Paclitaxel were evaluated on Chorioallantoic Membrane (CAM) of chick in the current experimental study. Methods: Ninety fertilized eggs of Ross race were arranged into 9 groups as follows: control, Dexamethasone, Paclitaxel, Pheromones of currant borer (Synanthedon tipuliformis); leopard moth (Zeuzera pyrina L. ) and pistachio twig borer (Kermania pistaciella)-alone, and each sex Pheromones plus Paclitaxel. On day 8 of chick embryo incubation, 50 μ l of each compound were applied to CAMs, and their effects were evaluated on day 9. Results: Compared with controls, application of each of the Pheromones alone is equally effective in reducing vessel length and branching points by 88% and 71%, respectively. Angiogenesis was suppressed (82%) by Paclitaxel and stimulated (20%) by Dexamethasone. Inhibitory effect of Paclitaxel on vascular branching points was further increased (7%) after combination treatment with each of three Pheromones. Pheromones of Z. pyrina and K. pistaciella were able to enhance (7%) antiangiogenic effect of Paclitaxel. Conclusion: The direct anti-angiogenic effects of these insect Pheromones and the incremental anti-angiogenic effect of each of them with Paclitaxel. This antiangiogenic effect seems independent from anti-inflammatory mechanisms. Therefore, we suggest that the effect of these Pheromones with Paclitaxel be studied on patients with Paclitaxel-resistant tumors.

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APA: Copy

Payambarpour, Zeynab Sadat, HASSANPOUR EZATTI, MAJID, & ASKARIANZADEH, ALIREZA. (2020). Inhibition of angiogenesis and improvement of the anti-angiogenic activity of paclitaxel by three insect sex pheromones in chicken chorioallantoic membrane. MEDICAL JOURNAL OF TABRIZ UNIVERSITY OF MEDICAL SCIENCES, 42(3 ), 245-253. SID. https://sid.ir/paper/383378/en

Vancouver: Copy

Payambarpour Zeynab Sadat, HASSANPOUR EZATTI MAJID, ASKARIANZADEH ALIREZA. Inhibition of angiogenesis and improvement of the anti-angiogenic activity of paclitaxel by three insect sex pheromones in chicken chorioallantoic membrane. MEDICAL JOURNAL OF TABRIZ UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2020;42(3 ):245-253. Available from: https://sid.ir/paper/383378/en

IEEE: Copy

Zeynab Sadat Payambarpour, MAJID HASSANPOUR EZATTI, and ALIREZA ASKARIANZADEH, “Inhibition of angiogenesis and improvement of the anti-angiogenic activity of paclitaxel by three insect sex pheromones in chicken chorioallantoic membrane,” MEDICAL JOURNAL OF TABRIZ UNIVERSITY OF MEDICAL SCIENCES, vol. 42, no. 3 , pp. 245–253, 2020, [Online]. Available: https://sid.ir/paper/383378/en

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