Evaluation of oxidative stress in platelet during storage of platelet concentrate

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Mohammadi Dahj Malihe; AMIRI FATEMEH; DEYHIM MOHAMMAD REZA; Nikoogftar Zarif Mahin

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Journal: Research in Medicine Year:2021 | Volume:44 | Issue:4 Page(s): 587-593

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Information Journal Paper

Title

Evaluation of oxidative stress in platelet during storage of platelet concentrate

Author(s)

Mohammadi Dahj Malihe | AMIRI FATEMEH | DEYHIM MOHAMMAD REZA | Nikoogftar Zarif Mahin | Issue Writer Certificate

Keywords

Platelet storage lesionQ1

Oxidative stressQ2

Platelet concentrateQ1

Platelet storageQ1

Abstract

Background: Platelets undergo a series of biochemical, functional, and morphological changes during storage that are collectively called Platelet storage damage, which can reduce platelet function and survival. Oxidative damage is one of the leading causes of Platelet storage damage. Therefore, in the present study, an attempt has been made to determine the effect of Oxidative stress on platelets during storage. This research was conducted in 2017 at the Research Center of the Iranian Blood Transfusion Organization. Materials and Methods: In the current experimental study, 10 Platelet concentrate bags prepared by platelet-rich plasma (PRP) were examined. Research parameters include measurement of mitochondrail reactive oxygen species (ROS), concentration of malondialdehyde (MDA), concentration of nitric oxide metabolites (nitrate / nitrite), activity of lactate dehydrogenase enzyme (LDH) and platelet count on days 1, 3, 5 and 7 of Platelet storage. Statistical analysis of variance was used to describe the obtained data Results: According to the results, ROS (16. 22± 37), MDA (11. 6± 22. 2) concentration and LDH enzyme activity (310± 3680) increased significantly (P<0. 001) while PLT count was significantly decreased (P<0. 001). Conclusion: It seems that oxidative damage occurred in platelet with increasing radical oxygen species and lipid peroxidation which can reduce platelet count and platelet viability during Platelet storage. Using antioxidant as an additive in Platelet concentrate may decrease oxidative damage and increase platelet viability and quality during storage.

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APA: Copy

Mohammadi Dahj, Malihe, AMIRI, FATEMEH, DEYHIM, MOHAMMAD REZA, & Nikoogftar Zarif, Mahin. (2021). Evaluation of oxidative stress in platelet during storage of platelet concentrate. PAJOUHESH DAR PEZESHKI, 44(4 ), 587-593. SID. https://sid.ir/paper/383384/en

Vancouver: Copy

Mohammadi Dahj Malihe, AMIRI FATEMEH, DEYHIM MOHAMMAD REZA, Nikoogftar Zarif Mahin. Evaluation of oxidative stress in platelet during storage of platelet concentrate. PAJOUHESH DAR PEZESHKI[Internet]. 2021;44(4 ):587-593. Available from: https://sid.ir/paper/383384/en

IEEE: Copy

Malihe Mohammadi Dahj, FATEMEH AMIRI, MOHAMMAD REZA DEYHIM, and Mahin Nikoogftar Zarif, “Evaluation of oxidative stress in platelet during storage of platelet concentrate,” PAJOUHESH DAR PEZESHKI, vol. 44, no. 4 , pp. 587–593, 2021, [Online]. Available: https://sid.ir/paper/383384/en

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