A QUANTITATIVE INVESTIGATION OF THE BID GENE EXPRESSION IN BIOPSIES FROM COLORECTAL ADENOMAS

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SADAT KIA FATEME; NAZEMALHOSSEINI MOJARAD EHSAN; FOROUZESH FLORA

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Paper Information

Journal: TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ) Year:2018 | Volume:76 | Issue:2 Page(s): 120-128

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Title

A QUANTITATIVE INVESTIGATION OF THE BID GENE EXPRESSION IN BIOPSIES FROM COLORECTAL ADENOMAS

Author(s)

SADAT KIA FATEME | NAZEMALHOSSEINI MOJARAD EHSAN | FOROUZESH FLORA | Issue Writer Certificate

Keywords

ADENOMATOUS POLYPSQ1

APOPTOSISQ2

BID GENEQ1

COLORECTAL CANCERQ2

Abstract

Background: Most of COLORECTAL CANCERs arise from intestinal polyps. Evaluating of the expression level of genes that are involved in tumors growth and development, may consider as diagnostic factor of malignancy in the polyps. Failure of APOPTOSIS is one of the causes of cancers. One of the key molecules in this pathway is BID GENE which connects the extrinsic to the intrinsic APOPTOSIS pathways. The aim of this study was to investigate the quantitative expression of BID GENE in colorectal ADENOMATOUS POLYPS compared to control group.Methods: The investigated population was chosen from the cases with colonic polyps that referred to the Taleghani Hospital, Tehran, Iran, from April 2014 to May 2016.22 biopsy samples from patients with ADENOMATOUS POLYPS and 10 samples from healthy individuals as control group were selected. Demographic and clinical properties were collected from patients' files. TheBid gene expression was evaluated using Real-time PCR by ABI 7500 (Applied Biosystems Inc., Foster City, CA, USA). Results were analyzed by the ABI 7500 system SDS version 2.3 and Graph Pad Prism, version 5 (GraphPad Software Inc., La Jolla, CA, USA). the expression changes of the intended gene in target groups were compared with the normal tissues using the 2-DDCT equation.Results: Based on the quantitative real-time PCR, the gene expression of BID GENE significantly increased in ADENOMATOUS POLYPS in comparison with the control group (healthy individuals) (RQ>2). Also, polyps were seen in ascending colon, transverse colon, descending colon and rectum showed increased expression compared to control group, but in the sigmoid section of the intestine, there was no change in expression of Bidgene compared to control group.Conclusion: According to the present study, the expression of BID GENE increased in ADENOMATOUS POLYPS, compared with the normal tissue (healthy group). It suggests that Bidgene by increasing the expression in response to the onset of dysplasia and disruption of the apoptotic cycle, it tries to compensate for the APOPTOSIS.

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References

EXPRESSION OF CD86 CO-STIMULATORY GENE IN COLON POLYPS

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APA: Copy

SADAT KIA, FATEME, NAZEMALHOSSEINI MOJARAD, EHSAN, & FOROUZESH, FLORA. (2018). A QUANTITATIVE INVESTIGATION OF THE BID GENE EXPRESSION IN BIOPSIES FROM COLORECTAL ADENOMAS. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), 76(2 ), 120-128. SID. https://sid.ir/paper/38465/en

Vancouver: Copy

SADAT KIA FATEME, NAZEMALHOSSEINI MOJARAD EHSAN, FOROUZESH FLORA. A QUANTITATIVE INVESTIGATION OF THE BID GENE EXPRESSION IN BIOPSIES FROM COLORECTAL ADENOMAS. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ)[Internet]. 2018;76(2 ):120-128. Available from: https://sid.ir/paper/38465/en

IEEE: Copy

FATEME SADAT KIA, EHSAN NAZEMALHOSSEINI MOJARAD, and FLORA FOROUZESH, “A QUANTITATIVE INVESTIGATION OF THE BID GENE EXPRESSION IN BIOPSIES FROM COLORECTAL ADENOMAS,” TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), vol. 76, no. 2 , pp. 120–128, 2018, [Online]. Available: https://sid.ir/paper/38465/en

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