The effect of 8 weeks high-intensity interval training and combined training on miR-16 expression in peripheral mononuclear blood cells of overweight/obese middle-aged women

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Pashaei Zhaleh; JAFARI AFSHAR; Alivand Mohammadreza

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Journal: MEDICAL JOURNAL OF TABRIZ UNIVERSITY OF MEDICAL SCIENCES Year:2021 | Volume:42 | Issue:6 Page(s): 745-755

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Title

The effect of 8 weeks high-intensity interval training and combined training on miR-16 expression in peripheral mononuclear blood cells of overweight/obese middle-aged women

Author(s)

Pashaei Zhaleh | JAFARI AFSHAR | Alivand Mohammadreza | Issue Writer Certificate

Keywords

Mir-16Q1

High-Intensity Interval TrainingQ1

Combined TrainingQ1

Overweight/ObesityQ1

Abstract

Background: MicroRNAs are short non-coding RNA molecules that regulate different biological processes through regulating the expression of different genes and the Mir-16 is one of the miRNAs that play an important role in obesity-related disorders. Therefore, the present study was conducted to determine the effect of High-Intensity Interval Training (HIIT) alone and combined with resistance training (CHRT) on Mir-16 expression in PBMCs of overweight/ obese middle-aged women. Methods: Twenty-four overweight/obese, inactive, health middle-aged women participated in two homogeneous groups HIIT (5 bouts of running at 80%– 85% of VO2max with active breaks at 60% of VO2max, 5 days/week, n=12) and CHRT protocols (3 day/week HIIT with 2 day/week resistance training protocol with 75-80% of 1-RM, n=12) for eight-week. Mir-16 expressions in PBMCs of overweight/obese middle-aged women were measured by real time-PCR before and 48h after the training protocols. Results: Expression of Mir-16 increased significantly in the both training protocols (HIIT: 2. 32 fold, p=0. 001 and CHRT: 4. 96, p=0. 006). However, there was no significant difference found between training protocols. Conclusion: The eight weeks of HIIT and CHRT training are lead to equally changes in the expression of Mir-16, as an anti-inflammatory epigenetic factor, in PBMCs of overweight/obese women.

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APA: Copy

Pashaei, Zhaleh, JAFARI, AFSHAR, & Alivand, Mohammadreza. (2021). The effect of 8 weeks high-intensity interval training and combined training on miR-16 expression in peripheral mononuclear blood cells of overweight/obese middle-aged women. MEDICAL JOURNAL OF TABRIZ UNIVERSITY OF MEDICAL SCIENCES, 42(6 ), 745-755. SID. https://sid.ir/paper/388497/en

Vancouver: Copy

Pashaei Zhaleh, JAFARI AFSHAR, Alivand Mohammadreza. The effect of 8 weeks high-intensity interval training and combined training on miR-16 expression in peripheral mononuclear blood cells of overweight/obese middle-aged women. MEDICAL JOURNAL OF TABRIZ UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2021;42(6 ):745-755. Available from: https://sid.ir/paper/388497/en

IEEE: Copy

Zhaleh Pashaei, AFSHAR JAFARI, and Mohammadreza Alivand, “The effect of 8 weeks high-intensity interval training and combined training on miR-16 expression in peripheral mononuclear blood cells of overweight/obese middle-aged women,” MEDICAL JOURNAL OF TABRIZ UNIVERSITY OF MEDICAL SCIENCES, vol. 42, no. 6 , pp. 745–755, 2021, [Online]. Available: https://sid.ir/paper/388497/en

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