Effect of Nigella Sativa Oil Extract on Leptin and Adiponectin in Type 2 Diabetic Patients: A Randomized, Double Blind, Placebo controlled Clinical Trial

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HOSSEINPOUR NIAZI SOMAYEH; HADI SAEID; MIRMIRAN PARVIN

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Journal: Research in Medicine Year:2021 | Volume:44 | Issue:4 Page(s): 521-525

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Title

Effect of Nigella Sativa Oil Extract on Leptin and Adiponectin in Type 2 Diabetic Patients: A Randomized, Double Blind, Placebo controlled Clinical Trial

Author(s)

HOSSEINPOUR NIAZI SOMAYEH | HADI SAEID | MIRMIRAN PARVIN | Issue Writer Certificate

Keywords

Nigella sativa oil extractQ1

LeptinQ2

AdiponectinQ2

TypeQ2

Abstract

Background: The effects of herbal medicine in management of chronic diseases, such as diabetes, are under investigation. One of the most recent herbal medicine for the management of diabetes is nigella Sativa. The mechanism of the effect of nigella Sativa on diabetes is not clear. One of the mechanisms that improves insulin resistance among Type 2 diabetes is an increase in Adiponectin concentration and a decrease in serum Leptin concentration, but only a few studies have examined the effect of nigella Sativa on Leptin and Adiponectin concentrations. The aim of the present doubleblind randomized controlled clinical trial was to investigate the effect of Nigella sativa oil extract on serum Leptin and Adiponectin concentrations in patients with Type 2 diabetes mellitus. Materials and methods: A total of 43 Type 2 diabetic patients, aged 55-30 years (20 women, age: 6. 3± 53. 7 years), were randomly assigned to intervention (n=23) and control (n=20) groups. Intervention group took 2 capsules (500 mg extract of black seed oil) per day, while control group took 2 capsules (500 mg, placebo) both for 8 weeks. Leptin and Adiponectin concentrations were measured at baseline and again after the-8week intervention. To calculate changes in Leptin and Adiponectin, baseline and end-of-intervention values were used to compare baseline and end-ofintervention values in each group using paired t-test. Results: Extract of black seed oil significantly decreased Leptin concentrations in the intervention group (baseline 0. 6± 7. 3; after intervention 0. 3 ± 5. 2, p < 0. 005) compared to the control group (baseline 0. 9 ± 7. 6, after intervention 0. 9 ± 7. 8, p=0. 41). There was no significant change in Adiponectin concentrations after both Nigella sativa oil extract and placebo consumption. Conclusion: It seems that Nigella sativa oil extract reduces serum Leptin concentrations in Type 2 diabetic patients; however, no significant effect on Adiponectin concentrations was found.

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APA: Copy

HOSSEINPOUR NIAZI, SOMAYEH, HADI, SAEID, & MIRMIRAN, PARVIN. (2021). Effect of Nigella Sativa Oil Extract on Leptin and Adiponectin in Type 2 Diabetic Patients: A Randomized, Double Blind, Placebo controlled Clinical Trial. PAJOUHESH DAR PEZESHKI, 44(4 ), 521-525. SID. https://sid.ir/paper/392567/en

Vancouver: Copy

HOSSEINPOUR NIAZI SOMAYEH, HADI SAEID, MIRMIRAN PARVIN. Effect of Nigella Sativa Oil Extract on Leptin and Adiponectin in Type 2 Diabetic Patients: A Randomized, Double Blind, Placebo controlled Clinical Trial. PAJOUHESH DAR PEZESHKI[Internet]. 2021;44(4 ):521-525. Available from: https://sid.ir/paper/392567/en

IEEE: Copy

SOMAYEH HOSSEINPOUR NIAZI, SAEID HADI, and PARVIN MIRMIRAN, “Effect of Nigella Sativa Oil Extract on Leptin and Adiponectin in Type 2 Diabetic Patients: A Randomized, Double Blind, Placebo controlled Clinical Trial,” PAJOUHESH DAR PEZESHKI, vol. 44, no. 4 , pp. 521–525, 2021, [Online]. Available: https://sid.ir/paper/392567/en

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