METHOTREXATE IN THE TREATMENT OF STEROID DEPENDENT ASTHMA

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DERAKHSHAN DEYLAMI GH.R.; MEHRABI S.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Journal: Tehran University Medical Journal Year:2000 | Volume:58 | Issue:2 Page(s): 35-40

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Information Journal Paper

Title

METHOTREXATE IN THE TREATMENT OF STEROID DEPENDENT ASTHMA

Author(s)

DERAKHSHAN DEYLAMI GH.R. | MEHRABI S. | Issue Writer Certificate

Keywords

CORTICOSTEROID DEPENDENT ASTHMAQ4

METHOTREXATEQ4

CROSSOVER TRIALQ4

Abstract

Despite the role of oral corticosteroids in management of sever asthma, use of these drugs needs careful awareness of its many side effects. There are controversies about the role of METHOTREXATE in lowering the need for corticosteroids in these patients. In this study an attempt has been made to determine METHOTREXATE effects in CORTICOSTEROID DEPENDENT ASTHMA. Six patients were entered in a double-blind placebo controlled CROSSOVER TRIAL and randomly allocated to two groups. Each group got a 12 weeks course of treatment with 15 milligrams of METHOTREXATE or placebo wich thereafter was changed to the other regimen. In comparison with placebo, METHOTREXATE caused a 62.5% less need for oral corticosteroid (P<0.01) and a 20% increase in FEV 1 (P<0.05). We concluded that the use of low doses of oral METHOTREXATE results in less need for oral corticosteroid in treatment of CORTICOSTEROID DEPENDENT ASTHMA.

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APA: Copy

DERAKHSHAN DEYLAMI, GH.R., & MEHRABI, S.. (2000). METHOTREXATE IN THE TREATMENT OF STEROID DEPENDENT ASTHMA. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), 58(2), 35-40. SID. https://sid.ir/paper/39317/en

Vancouver: Copy

DERAKHSHAN DEYLAMI GH.R., MEHRABI S.. METHOTREXATE IN THE TREATMENT OF STEROID DEPENDENT ASTHMA. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ)[Internet]. 2000;58(2):35-40. Available from: https://sid.ir/paper/39317/en

IEEE: Copy

GH.R. DERAKHSHAN DEYLAMI, and S. MEHRABI, “METHOTREXATE IN THE TREATMENT OF STEROID DEPENDENT ASTHMA,” TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), vol. 58, no. 2, pp. 35–40, 2000, [Online]. Available: https://sid.ir/paper/39317/en

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