MOLECULAR GENETICS AND GENE THERAPY IN ESOPHAGEAL CANCER: A REVIEW ARTICLE

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NOORI DALOII MOHAMMAD REZA; MAHERONNAGHSH RADIN; SAYYAH MOHAMMAD KAZEM

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Journal: Tehran University Medical Journal Year:2011 | Volume:69 | Issue:6 Page(s): 331-343

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Title

MOLECULAR GENETICS AND GENE THERAPY IN ESOPHAGEAL CANCER: A REVIEW ARTICLE

Author(s)

NOORI DALOII MOHAMMAD REZA | MAHERONNAGHSH RADIN | SAYYAH MOHAMMAD KAZEM | Issue Writer Certificate

Keywords

DYSPLASIAQ2

ESOPHAGEAL CANCERQ2

GASTRO ESOPHAGEAL REFLUXQ2

GENE THERAPYQ2

METAPLASIAQ3

MOLECULAR GENETICSQ3

Abstract

Background: With approximately 386, 000 deaths per year, ESOPHAGEAL CANCER is the 6th most common cause of death due to cancer in the world. This cancer, like any other cancer, is the outcome of genetic alterations or environmental factors such as tobacco smoke and gastro-esophageal reflux. Tobacco smoking is a major etiologic factor for esophageal squamous cell carcinoma in western countries, and it increases the risk by approximately 3 to 5 folds. Chronic gastro-esophageal reflux usually leads to the replacement of squamous mucosa by intestinal-type Barrett’s met aplastic mucosa which is considered the most important factor causing esophageal adenocarcinoma. In contrast to esophageal adenocarcinoma, different risk factors and mechanisms, such as mutations in oncogenes and tumor suppressor genes, play an important role in causing esophageal squamous cell carcinoma. Molecular studies on ESOPHAGEAL CANCERs have revealed frequent genetic abnormalities in esophageal squamous cell carcinoma and adenocarcinoma, including altered expression of p53, p16, cyclin D1, EGFR, E-cadherin, COX-2, iNOS, RARs, Rb, hTERT, p21, APC, c-MYC, VEGF, TGT-a and NF-kB. Many studies have focused on the role of different polymorphisms such as aldehyde dehydrogenase2 and alcohol dehydrogenase 2 in causing ESOPHAGEAL CANCER. Different agents including be statin, cur cumin, black raspberries, 5-lipoxygenase (LOX) and COX-2inhibitors have been found to play a role in inhibiting esophageal carcinogenesis. Different GENE THERAPY approaches including p53 and p21WAF1 replacement gene therapies and therapy by suicide genes have also been experimented. Moreover, efforts have been made to use nanotechnology and aptamer technology in this regard.

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APA: Copy

NOORI DALOII, MOHAMMAD REZA, MAHERONNAGHSH, RADIN, & SAYYAH, MOHAMMAD KAZEM. (2011). MOLECULAR GENETICS AND GENE THERAPY IN ESOPHAGEAL CANCER: A REVIEW ARTICLE. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), 69(6), 331-343. SID. https://sid.ir/paper/39431/en

Vancouver: Copy

NOORI DALOII MOHAMMAD REZA, MAHERONNAGHSH RADIN, SAYYAH MOHAMMAD KAZEM. MOLECULAR GENETICS AND GENE THERAPY IN ESOPHAGEAL CANCER: A REVIEW ARTICLE. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ)[Internet]. 2011;69(6):331-343. Available from: https://sid.ir/paper/39431/en

IEEE: Copy

MOHAMMAD REZA NOORI DALOII, RADIN MAHERONNAGHSH, and MOHAMMAD KAZEM SAYYAH, “MOLECULAR GENETICS AND GENE THERAPY IN ESOPHAGEAL CANCER: A REVIEW ARTICLE,” TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), vol. 69, no. 6, pp. 331–343, 2011, [Online]. Available: https://sid.ir/paper/39431/en

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