MOLECULAR GENETIC, DIAGNOSIS, PREVENTION AND GENE THERAPY IN PROSTATIC CANCER: REVIEW ARTICLE

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NOURI DALOUEI M.R.; EBRAHIMZADEH VESAL E.

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Journal: TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ) Year:2009 | Volume:67 | Issue:1 Page(s): 1-14

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Information Journal Paper

Title

MOLECULAR GENETIC, DIAGNOSIS, PREVENTION AND GENE THERAPY IN PROSTATIC CANCER: REVIEW ARTICLE

Author(s)

NOURI DALOUEI M.R. | EBRAHIMZADEH VESAL E. | Issue Writer Certificate

Keywords

MOLECULAR GENETICQ3

DIAGNOSISQ3

PREVENTIONQ2

GENE THERAPYQ3

PROSTATE CANCERQ2

Abstract

The prostate is a small gland located below the bladder and upper part of the urethra. In developed countries PROSTATE CANCER is the second common cancer (after skin cancer), and also the second leading cause of cancer death (after lung cancer) among men. The several studies have been shown PROSTATE CANCER familial aggregation. The main reason for this aggregation is inheritance included genes. The family history is an important risk factor for developing the disease. The genes AR, CYP17, SRD5A2, HSD3B1 and HSD3B2 are all intimately involved in androgen metabolism and cell proliferation in the prostate. Each shows intraspecific polymorphism and variation among racial-ethnic groups that is associated with the risk of PROSTATE CANCER. Some of genes expressed in the prostate are in association with the production of seminal fluid and also with PROSTATE CANCER. Epigenetic modifications, specifically DNA hypermethylation, are believed to play an important role in the down-regulation of genes important for protection against PROSTATE CANCER. In PROSTATE CANCER numerous molecular and genetic aberrations have been described. It is now well established that cancer cells exhibit a number of genetic defects in apoptotic pathways. In this review article, the most recent data in MOLECULAR GENETIC, PREVENTION and especially GENE THERAPY in PROSTATE CANCER are introduced.

Cites

UP REGULATION OF CD82 GENE IN PROSTATE CANCER PC-3 CELL LINE TREATED WITH SILIBININ

References

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APA: Copy

NOURI DALOUEI, M.R., & EBRAHIMZADEH VESAL, E.. (2009). MOLECULAR GENETIC, DIAGNOSIS, PREVENTION AND GENE THERAPY IN PROSTATIC CANCER: REVIEW ARTICLE. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), 67(1), 1-14. SID. https://sid.ir/paper/38769/en

Vancouver: Copy

NOURI DALOUEI M.R., EBRAHIMZADEH VESAL E.. MOLECULAR GENETIC, DIAGNOSIS, PREVENTION AND GENE THERAPY IN PROSTATIC CANCER: REVIEW ARTICLE. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ)[Internet]. 2009;67(1):1-14. Available from: https://sid.ir/paper/38769/en

IEEE: Copy

M.R. NOURI DALOUEI, and E. EBRAHIMZADEH VESAL, “MOLECULAR GENETIC, DIAGNOSIS, PREVENTION AND GENE THERAPY IN PROSTATIC CANCER: REVIEW ARTICLE,” TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), vol. 67, no. 1, pp. 1–14, 2009, [Online]. Available: https://sid.ir/paper/38769/en

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