CLINICAL EVALUATION OF SERUM CEA AND CA15-3 IN PATIENTS WITH BREAST CANCER

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SEYLANIAN TOUSI M.; SALEHI M.H.; SAEIDI SAEDI HAMID

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Journal: Journal of Guilan University of Medical Sciences Year:2006 | Volume:15 | Issue:58 Page(s): 7-14

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Title

CLINICAL EVALUATION OF SERUM CEA AND CA15-3 IN PATIENTS WITH BREAST CANCER

Author(s)

SEYLANIAN TOUSI M. | SALEHI M.H. | SAEIDI SAEDI HAMID | Issue Writer Certificate

Keywords

BREAST NEOPLASMSQ3

SENSITIVITY AND SPECIFICITYQ2

TUMOR MARKERS BIOLOGICALQ3

Abstract

Introduction: Tumor markers are useful means for obtaining information about some malignant tumors whilst causing minimal inconvenience and cost.Objective: The purpose of this study was to evaluate the value of CA 15-3 and CEA in patients with breast carcinoma.Materials and Methods: This retrospective study was performed on 604 patients (mean age= 47 years) who were referred for treatment to oncology departments of Ghaem and Omid hospitals of (Mashhad Iran) from 1999 to 2004. CEA (cut off, 5 ng/ml) and CA 15-3 (cut off, 40 U/ml) had been measured with radioimmunoassay method for every patient (1- 10 times). Results: Stage I to IV was found in 25, 370, 165 and 44 patients respectively at the time of referral. With a mean follow up time of 18 months, from 560 nonmetastatic patients, 76 (13.6%) cases experienced recurrence. The sensitivity of CEA and CA 15-3 measurements in patients with overt metastasis or up to one month before the detection of recurrence were 56.4% and 90% respectively. CEA and CA 15-3 were measured 2 to 8 months before the detection of metastasis in 44 patients from which raising the levels of these markers were found in 7 (15.9%) and 23 (52.2%) cases respectively. Among 249 disease free patients who had been followed for more than 18 months, false positive levels of CEA and CA15-3 were found in 7 (2.8%) and 4 (1.7%) cases respectively.Conclusion: Considering the low number of false positive results in recurrent free patients, both CEA and CA15-3 showed good specificity. The sensitivity of CA15-3 is good for the detection of overt metastasis. However CA15-3 has a modest sensitivity in patients with minimal disease. CEA has a much lower sensitivity compared to CA15-3. However, the positive test can confirm the result of CA15-3 in metastatic setting.

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APA: Copy

SEYLANIAN TOUSI, M., SALEHI, M.H., & SAEIDI SAEDI, HAMID. (2006). CLINICAL EVALUATION OF SERUM CEA AND CA15-3 IN PATIENTS WITH BREAST CANCER. JOURNAL OF GUILAN UNIVERSITY OF MEDICAL SCIENCES, 15(58), 7-14. SID. https://sid.ir/paper/39752/en

Vancouver: Copy

SEYLANIAN TOUSI M., SALEHI M.H., SAEIDI SAEDI HAMID. CLINICAL EVALUATION OF SERUM CEA AND CA15-3 IN PATIENTS WITH BREAST CANCER. JOURNAL OF GUILAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2006;15(58):7-14. Available from: https://sid.ir/paper/39752/en

IEEE: Copy

M. SEYLANIAN TOUSI, M.H. SALEHI, and HAMID SAEIDI SAEDI, “CLINICAL EVALUATION OF SERUM CEA AND CA15-3 IN PATIENTS WITH BREAST CANCER,” JOURNAL OF GUILAN UNIVERSITY OF MEDICAL SCIENCES, vol. 15, no. 58, pp. 7–14, 2006, [Online]. Available: https://sid.ir/paper/39752/en

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