Comparing the Effects of Oral Oxycodone and Intravenous Ketorolac on Postoperative Pain of Laparoscopic Cholecystectomy

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MOTTAGHI KAMRAN; NASHIBI MASOUD; SAFARI FARHAD; Asgari Sogol; SEZARI PARISA

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Journal: JOURNAL OF IRANIAN SOCIETY ANAESTHESIOLOGY AND INTENSIVE CARE Year:2019 | Volume:41 | Issue:1 (105) Page(s): 21-28

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Title

Comparing the Effects of Oral Oxycodone and Intravenous Ketorolac on Postoperative Pain of Laparoscopic Cholecystectomy

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Keywords

oxycodoneQ1

ketorolacQ1

postoperative painQ3

laparoscopyQ2

Abstract

Background and Aim: oxycodone is a μ-opioid receptor agonist and is generally indicated for the relief of moderate to severe pain. The aim of this study was to compare the analgesic efficacy of oral oxycodone and intravenous ketorolac for postoperative pain in patients undergoing laparoscopic cholecystectomy. Materials and methods: In this double blinded study 60 patients underwent laparoscopic cholecystectomy classified into 2 groups ketorolac (n=30) and oxycodone (n=30) randomly. Anesthesia induction and intubation was the same in both groups. postoperative pain, blood pressure and heart rate was measured 1, 2, 4, 6 and 12 hours after surgery in both groups. Post-operative nausea and vomiting and shivering also was compared between two groups. Results: there was no significant differences between two groups considering age, gender and ASA class. Also, no significant difference between two groups comparing systolic and diastolic blood pressure and heart rate in mentioned hours (P>0. 05). Mean NRS was significantly lower in oxycodone in compare with ketorolac group, except in sixth hour (p<0. 05). Need for morphine consumption in ketorolac group was meaningfully higher than the other group (p<0. 001). Incidence of postoperative nausea and vomiting was a little higher in oxycodone group. Conclusion: oral oxycodone is a good choice in controlling postoperative pain considering efficacy, easily consumption and low incidence of adverse effect.

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APA: Copy

MOTTAGHI, KAMRAN, NASHIBI, MASOUD, SAFARI, FARHAD, Asgari, Sogol, & SEZARI, PARISA. (2019). Comparing the Effects of Oral Oxycodone and Intravenous Ketorolac on Postoperative Pain of Laparoscopic Cholecystectomy. JOURNAL OF IRANIAN SOCIETY ANAESTHESIOLOGY AND INTENSIVE CARE, 41(1 (105) ), 21-28. SID. https://sid.ir/paper/398262/en

Vancouver: Copy

MOTTAGHI KAMRAN, NASHIBI MASOUD, SAFARI FARHAD, Asgari Sogol, SEZARI PARISA. Comparing the Effects of Oral Oxycodone and Intravenous Ketorolac on Postoperative Pain of Laparoscopic Cholecystectomy. JOURNAL OF IRANIAN SOCIETY ANAESTHESIOLOGY AND INTENSIVE CARE[Internet]. 2019;41(1 (105) ):21-28. Available from: https://sid.ir/paper/398262/en

IEEE: Copy

KAMRAN MOTTAGHI, MASOUD NASHIBI, FARHAD SAFARI, Sogol Asgari, and PARISA SEZARI, “Comparing the Effects of Oral Oxycodone and Intravenous Ketorolac on Postoperative Pain of Laparoscopic Cholecystectomy,” JOURNAL OF IRANIAN SOCIETY ANAESTHESIOLOGY AND INTENSIVE CARE, vol. 41, no. 1 (105) , pp. 21–28, 2019, [Online]. Available: https://sid.ir/paper/398262/en

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