INFLUENCE OF DRUG AND POLYMER HPMC K15M PARTICLE SIZE ON THE RELEASE RATE OF THEOPHYLLINE FROM POLYMER MATRICES

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

ENAYATI FARD REZA; AKBARI JAFAR; SAEIDI MAJID; RAZEGHIAN OMID

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES Year:2013 | Volume:22 | Issue:98 Page(s): 0-0

Download Full-Text

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Verion

View:

1,037

Download:

Cites:

Information Journal Paper

Title

INFLUENCE OF DRUG AND POLYMER HPMC K15M PARTICLE SIZE ON THE RELEASE RATE OF THEOPHYLLINE FROM POLYMER MATRICES

Author(s)

ENAYATI FARD REZA | AKBARI JAFAR | SAEIDI MAJID | RAZEGHIAN OMID | Issue Writer Certificate

Keywords

THEOPHYLLINEQ3

POLYMERQ2

PARTICLE SIZEQ2

RELEASE RATEQ2

Abstract

Background and purpose: One of the methods of preparing controlled-release dosage forms is the incorporation of drug in a matrix containing a hydrophilic rate-controlling POLYMER. Drug-polymer ratio, drug PARTICLE SIZE and HPMC PARTICLE SIZE have been identified as modifiers of drug release. This study evaluated the relationship and influence of formulation factors such as drug-HPMC ratio and PARTICLE SIZE of drug and HPMC on drug release from matrices containing HPMC K 15 M and thophylline as model drug.Materials and methods: Theopylline tablets were obtained by the direct compression method using different PARTICLE SIZEs and ratio of THEOPHYLLINE and HPMC K15M. The physicochemical properties of prepared tablets were investigated. Drug RELEASE RATE was also studied using USP I dissolution apparatus at pH 1.2 and 7.2. From different formulations the theopylline release was analyzed and then the data was fitted to Kinetic models.Results: The results of the present study showed that the rates of THEOPHYLLINE release from HPMC K15 M matrices are mainly controlled by the drug-HPMC ratio. The drug and HPMC PARTICLE SIZE also influenced the drug release parameters, although to a lesser extent.Conclusion: The main factor influencing the drug release from formulations is the POLYMER content. There is direct relationship between the POLYMER PARTICLE SIZE and drug release. However, there is an inverse relationship between the drug PARTICLE SIZE and release of THEOPHYLLINE.

Cites

No record.

References

No record.

Cite

APA: Copy

ENAYATI FARD, REZA, AKBARI, JAFAR, SAEIDI, MAJID, & RAZEGHIAN, OMID. (2013). INFLUENCE OF DRUG AND POLYMER HPMC K15M PARTICLE SIZE ON THE RELEASE RATE OF THEOPHYLLINE FROM POLYMER MATRICES. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, 22(98), 0-0. SID. https://sid.ir/paper/405784/en

Vancouver: Copy

ENAYATI FARD REZA, AKBARI JAFAR, SAEIDI MAJID, RAZEGHIAN OMID. INFLUENCE OF DRUG AND POLYMER HPMC K15M PARTICLE SIZE ON THE RELEASE RATE OF THEOPHYLLINE FROM POLYMER MATRICES. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2013;22(98):0-0. Available from: https://sid.ir/paper/405784/en

IEEE: Copy

REZA ENAYATI FARD, JAFAR AKBARI, MAJID SAEIDI, and OMID RAZEGHIAN, “INFLUENCE OF DRUG AND POLYMER HPMC K15M PARTICLE SIZE ON THE RELEASE RATE OF THEOPHYLLINE FROM POLYMER MATRICES,” JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, vol. 22, no. 98, pp. 0–0, 2013, [Online]. Available: https://sid.ir/paper/405784/en

Related Journal Papers