EFFECT OF SURFACTANTS ON RELEASE RATE OF PROPRANOLOL HCL, FROM HPMC MATRICES

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SIAHI SHADBAD M.R.; NOKHOUDCHI A.; FARID J.

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Journal: PHARMACEUTICAL SCIENCES Year:2001 | Volume:- | Issue:1 Page(s): 33-44

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Title

EFFECT OF SURFACTANTS ON RELEASE RATE OF PROPRANOLOL HCL, FROM HPMC MATRICES

Author(s)

SIAHI SHADBAD M.R. | NOKHOUDCHI A. | FARID J. | Issue Writer Certificate

Keywords

PROPRANOLOLQ3

SURFACTANTSQ3

REKASE RATEQ3

HPMC MATRICESQ3

RELEASE KINETICQ3

Abstract

Several studies have been shown that SURFACTANTS are able to increase release rate of drugs from HPMC MATRICES. The present study investigates the effects of various SURFACTANTS )nonionic SURFACTANTS e.g. Tween 80 with HLB=15 and Arlacel60 with HLB=4.7, sodium lauryl sulphate as an anionic surfactant and cetyl trimethyl ammonium bromide as a cationic surfactant) with different concentrations ranging from 0-10% w/w on the release rate of PROPRANOLOL hydrochloride from HPMC MATRICES. The results showed that an increase in the concentration of the surfactant with opposite charge to the drug resulted in a reduction in the release rate of PROPRANOLOL from HPMC MATRICES. It was also found that the surfactant with the same charge as the drug had not considerable effect on the release rate of PROPRANOLOL. The use of nonionic surfactant with high HLB caused an increase in the release rate of the drug, whereas using the low HLB. surfactant produced a reduction in release rate. The increase in release rate of the drug in presence of surfactant is attributed to an increase in wettability of tablet surfaces, reduction in surface tension, micellar solubilization and increase in drug solubility. The reduction in release rate of the drug could be due to the formation of insoluble complex between the drug of gel layer around matrix and lipophilicity of the matrix surfaces. Studies on the RELEASE KINETIC of the drug from HPMC MATRICES showed that both diffusion and erosion mechanisms are responsible for the release of PROPRANOLOL.

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APA: Copy

SIAHI SHADBAD, M.R., NOKHOUDCHI, A., & FARID, J.. (2001). EFFECT OF SURFACTANTS ON RELEASE RATE OF PROPRANOLOL HCL, FROM HPMC MATRICES. PHARMACEUTICAL SCIENCES, -(1), 33-44. SID. https://sid.ir/paper/48476/en

Vancouver: Copy

SIAHI SHADBAD M.R., NOKHOUDCHI A., FARID J.. EFFECT OF SURFACTANTS ON RELEASE RATE OF PROPRANOLOL HCL, FROM HPMC MATRICES. PHARMACEUTICAL SCIENCES[Internet]. 2001;-(1):33-44. Available from: https://sid.ir/paper/48476/en

IEEE: Copy

M.R. SIAHI SHADBAD, A. NOKHOUDCHI, and J. FARID, “EFFECT OF SURFACTANTS ON RELEASE RATE OF PROPRANOLOL HCL, FROM HPMC MATRICES,” PHARMACEUTICAL SCIENCES, vol. -, no. 1, pp. 33–44, 2001, [Online]. Available: https://sid.ir/paper/48476/en

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