PRESENCE OF OXYTOCIN RECEPTORS IN EMBRYONIC STEM CELLS AND THE EFFECTS OF OXYTOCIN HORMONE ON MOUSE EMBRYONIC STEM CELL-DERIVED CARDIOMOCYTE DIFFERENTIATION

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HATAMI L.; REZAZADEH VALOUJERDI M.; MOULA SEYED JAVAD

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Journal: Anatomical Sciences Journal Year:2008 | Volume:5 | Issue:21-22 Page(s): 217-230

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Title

PRESENCE OF OXYTOCIN RECEPTORS IN EMBRYONIC STEM CELLS AND THE EFFECTS OF OXYTOCIN HORMONE ON MOUSE EMBRYONIC STEM CELL-DERIVED CARDIOMOCYTE DIFFERENTIATION

Author(s)

HATAMI L. | REZAZADEH VALOUJERDI M. | MOULA SEYED JAVAD | Issue Writer Certificate

Keywords

MOUSE EMBRYONIC STEM CELLSQ3

CARDIOMYOCYTE DIFFERENTIATIONQ3

OXYTOCINQ3

OXYTOCIN RECEPTORSQ3

Abstract

Purpose: This study sought to investigate the presence of OXYTOCIN receptors and the possible biological role of OXYTOCIN as an effective factor in the differentiationof embryonic stem cells into cardiomyocytes. Materials and Methods: Mouse ESCs were cultivated in hanging drops to form embryoid bodies (EBs). The EBs were then treated with and without OXYTOCIN (experimental and control groups). Up to 30 days after plating, contraction and beating frequency were monitored and evaluated daily the characteristics of the ESC-derived cardiomyocytes were assessed by immunocytochemistry and reverse transcription-polymerase chain reaction (RT-PCR). Results: In the experimental group, the percentage of the EBs with spontaneous contraction was significantly increased from 17th day onward. The beating cells of groups, stained positive with anti a-actinin, desmin, cardiactroponin I and connexin antibodies. OXYTOCIN receptors were detected on the ESCs and derived-differentiated cells. In addition, cardiac-specific genes such as cardiac a- and b-myosin heavy chain, myosin light chain-2v, and atrial natriuretic factor were also detected in the ESC-derived differentiated cells of both groups. In the experimental group, all the specific genes with the exception of α-myosin heavy chain, were more pronounced at the early stage of cardiomyocyte development.Conclusion: OXYTOCIN has receptors on undifferentiated ESCs and derived differentiated cells, it can play role in development of cardiomyocytes during embryonic period.

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References

DIFFERENTIATION OF P19 CARCINOMA CELL LINE INTO CARDIOMYOCYTES BY OXYTOCIN HORMONE

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APA: Copy

HATAMI, L., REZAZADEH VALOUJERDI, M., & MOULA, SEYED JAVAD. (2008). PRESENCE OF OXYTOCIN RECEPTORS IN EMBRYONIC STEM CELLS AND THE EFFECTS OF OXYTOCIN HORMONE ON MOUSE EMBRYONIC STEM CELL-DERIVED CARDIOMOCYTE DIFFERENTIATION. JOURNAL OF IRANIAN ANATOMICAL SCIENCES, 5(21-22), 217-230. SID. https://sid.ir/paper/405808/en

Vancouver: Copy

HATAMI L., REZAZADEH VALOUJERDI M., MOULA SEYED JAVAD. PRESENCE OF OXYTOCIN RECEPTORS IN EMBRYONIC STEM CELLS AND THE EFFECTS OF OXYTOCIN HORMONE ON MOUSE EMBRYONIC STEM CELL-DERIVED CARDIOMOCYTE DIFFERENTIATION. JOURNAL OF IRANIAN ANATOMICAL SCIENCES[Internet]. 2008;5(21-22):217-230. Available from: https://sid.ir/paper/405808/en

IEEE: Copy

L. HATAMI, M. REZAZADEH VALOUJERDI, and SEYED JAVAD MOULA, “PRESENCE OF OXYTOCIN RECEPTORS IN EMBRYONIC STEM CELLS AND THE EFFECTS OF OXYTOCIN HORMONE ON MOUSE EMBRYONIC STEM CELL-DERIVED CARDIOMOCYTE DIFFERENTIATION,” JOURNAL OF IRANIAN ANATOMICAL SCIENCES, vol. 5, no. 21-22, pp. 217–230, 2008, [Online]. Available: https://sid.ir/paper/405808/en

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