INVESTIGATING THE CYTOTOXIC EFFECTS OF ETHANOLIC EXTRACT OFFERULA ASSAFOETIDA RESIN ON HEPG2 CELL LINE

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SADOOGHI S.D.; NEZHAD SHAHROKHABADI KH.; ZAFAR BALANEZHAD S.; BAHARARA J.

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Journal: Feyz Medical Sciences Journal Year:2013 | Volume:17 | Issue:4 Page(s): 323-330

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Title

INVESTIGATING THE CYTOTOXIC EFFECTS OF ETHANOLIC EXTRACT OFFERULA ASSAFOETIDA RESIN ON HEPG2 CELL LINE

Author(s)

SADOOGHI S.D. | NEZHAD SHAHROKHABADI KH. | ZAFAR BALANEZHAD S. | BAHARARA J. | Issue Writer Certificate

Keywords

HEPG2Q2

RESIN OF FERULA ASSA-FOETIDAQ1

CYTOTOXICQ2

Abstract

Background: RESIN OF FERULA ASSA-FOETIDA has medicinal properties and various studies have shown its antioxidant and anticancer effects. The aim of this study was to evaluate the CYTOTOXIC effect of ethanolic extract of Ferula assa-foetida resin on HepG2 cell line.Materials and Methods: In this experimental study, the effect of ethanolic extract of Ferula assa-foetida resin on HepG2 cell line and L929 normal cell line was investigated. The RPMI medium contains L-glutamine, penicillin, streptomycin and 10% FBS. Morphological changes were evaluated using an inverted microscope 24, 48, 72, 96 hours after adding the RESIN OF FERULA ASSA-FOETIDA extract (10, 50, 100, 200 mg/ml). Cell viability was determined using MTT assay.Results: Ethanolic extract of Ferula assa-foetida resin (50, 100, 200 mg/ml) were induced morphological changes in HepG2 cells after 24 hours which were prominent after 48, 72 and 96 hours. At concentrations of 100 and 200 mg/ml, morphological changes were observed in normal cells. Results of MTT assay showed a significant decrease in viability of HepG2 cells at concentrations of 50, 100, 200 mg/ml. Concentrations of 100 and 200 mg/ml significantly reduced the viability of L929 cell (P<0.05).Conclusion: Although Ferula assa-foetida resin (50 mg/ml) has CYTOTOXIC effects on HepG2 cell line, but at this concentration the extract have no CYTOTOXIC effect on normal cells.Therefore, this concentration can destroy cancer cells with minimal damage to normal cells.

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APA: Copy

SADOOGHI, S.D., NEZHAD SHAHROKHABADI, KH., ZAFAR BALANEZHAD, S., & BAHARARA, J.. (2013). INVESTIGATING THE CYTOTOXIC EFFECTS OF ETHANOLIC EXTRACT OFFERULA ASSAFOETIDA RESIN ON HEPG₂ CELL LINE. FEYZ, 17(4), 323-330. SID. https://sid.ir/paper/40866/en

Vancouver: Copy

SADOOGHI S.D., NEZHAD SHAHROKHABADI KH., ZAFAR BALANEZHAD S., BAHARARA J.. INVESTIGATING THE CYTOTOXIC EFFECTS OF ETHANOLIC EXTRACT OFFERULA ASSAFOETIDA RESIN ON HEPG₂ CELL LINE. FEYZ[Internet]. 2013;17(4):323-330. Available from: https://sid.ir/paper/40866/en

IEEE: Copy

S.D. SADOOGHI, KH. NEZHAD SHAHROKHABADI, S. ZAFAR BALANEZHAD, and J. BAHARARA, “INVESTIGATING THE CYTOTOXIC EFFECTS OF ETHANOLIC EXTRACT OFFERULA ASSAFOETIDA RESIN ON HEPG₂ CELL LINE,” FEYZ, vol. 17, no. 4, pp. 323–330, 2013, [Online]. Available: https://sid.ir/paper/40866/en

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