OPPOSITE EFFECT OF NALOXONE ON INFERTILITY INDUCED BY NITRIC OXIDE SYSTEM IN AN ANIMAL MODEL OF POLYCYSTIC OVARY

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LAKZAEI FATEMEH; KARAMI MANIZHEH; JALALI NADOUSHAN MOHAMMAD REZA; HASSANI FATEMEH

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Journal: DANESHVAR MEDICINE Year:2014 | Volume:21 | Issue:110 Page(s): 0-0

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Title

OPPOSITE EFFECT OF NALOXONE ON INFERTILITY INDUCED BY NITRIC OXIDE SYSTEM IN AN ANIMAL MODEL OF POLYCYSTIC OVARY

Author(s)

LAKZAEI FATEMEH | KARAMI MANIZHEH | JALALI NADOUSHAN MOHAMMAD REZA | HASSANI FATEMEH | Issue Writer Certificate

Keywords

POLYCYSTIC OVARIAN SYNDROMEQ2

FERTILITYQ2

L-ARGININEQ2

NITRIC OXIDEQ2

NALOXONEQ2

Abstract

Background and Objective: Evidence exist that POLYCYSTIC OVARIAN SYNDROME (PCOS) is responsible for a high percentage of women infertility during reproductive age. In this study, the correction of this problem by hyper-activation of NITRIC OXIDE (NO) system was studied in rats.Materials and Methods: Female Wistar rats (weighing 200-250 g) were kept as virgin diestrous under standard conditions. One group of the rats was i.p. injected with L-ARGININE (50 mg/kg) through a period lasting nine days/once a day. Another group received NALOXONE (0.4 mg/kg), 30 min prior to i.p. injection of L-ARGININE during the experimental phase. The third group was injected with a single dose of NALOXONE (0.4 mg/kg, i.p.). The control group solely received saline (1 ml/kg, i.p.).Results: Ovaries from L-ARGININE treated rats showed polycystic characteristics in comparison with the control; this feature was resolved in the NALOXONE treated groups. The endometrium due to L-ARGININE showed inflammation, however, its growth or folding were significant in NALOXONE treated rats.Conclusion: NALOXONE intervenes with the PCOS induced by over-activation of NOS. This research likely represents the case of infertility in the animal model of PCOS. The study may open a new gate towards the NALOXONE efficacy on infertility induced of PCOS.

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APA: Copy

LAKZAEI, FATEMEH, KARAMI, MANIZHEH, JALALI NADOUSHAN, MOHAMMAD REZA, & HASSANI, FATEMEH. (2014). OPPOSITE EFFECT OF NALOXONE ON INFERTILITY INDUCED BY NITRIC OXIDE SYSTEM IN AN ANIMAL MODEL OF POLYCYSTIC OVARY. DANESHVAR MEDICINE, 21(110), 0-0. SID. https://sid.ir/paper/409626/en

Vancouver: Copy

LAKZAEI FATEMEH, KARAMI MANIZHEH, JALALI NADOUSHAN MOHAMMAD REZA, HASSANI FATEMEH. OPPOSITE EFFECT OF NALOXONE ON INFERTILITY INDUCED BY NITRIC OXIDE SYSTEM IN AN ANIMAL MODEL OF POLYCYSTIC OVARY. DANESHVAR MEDICINE[Internet]. 2014;21(110):0-0. Available from: https://sid.ir/paper/409626/en

IEEE: Copy

FATEMEH LAKZAEI, MANIZHEH KARAMI, MOHAMMAD REZA JALALI NADOUSHAN, and FATEMEH HASSANI, “OPPOSITE EFFECT OF NALOXONE ON INFERTILITY INDUCED BY NITRIC OXIDE SYSTEM IN AN ANIMAL MODEL OF POLYCYSTIC OVARY,” DANESHVAR MEDICINE, vol. 21, no. 110, pp. 0–0, 2014, [Online]. Available: https://sid.ir/paper/409626/en

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