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Information Journal Paper

Title

HIGH INTENSITY INTERVAL TRAINING INHIBITS AUTOPHAGY IN THE HEART TISSUE OF TYPE 2 DIABETIC RATS BY DECREASING THE CONTENT OF FOXO3A AND BECLIN-1 PROTEINS

Pages

  292-299

Abstract

 Background: Diabetic cardiomyopathy is a complication Type 2 Diabetes mellitus that can lead to cardiac muscle autophagy through the proteins FOXO3a and Beclin-1. Therefore, the aim of this study is to investigate the effect of 8 weeks High Intensity Interval Training (HIIT) on the content of FOXO3a and Beclin-1 proteins in Heart Muscle tissue of Sprague-Dawley rats with type 2 diabetic rats. Methods: In this experimental study, 12 two-month-old Sprague-Dawley rats with a mean weight of 270± 20 g were selected. After diabetic induction with STZ and Nicotinamide, rats were randomly assigned to two groups, diabetic training (6 heads) and diabetic control (6 heads). The training group trained for 4 days a week in accordance with the training program (each session 42 minutes, 10-30 m/m) for 8 weeks, while the control group did not have any training program. Also, rats did not receive any insulin treatment during the study period. The independent t-test was used to analyze the data. Significance level is considered p≤ 0. 05. Results: Eight weeks of HIIT training resulted in a significant decrease in FOXO3a (P=0. 008) and Beclin-1 (P=0. 002) proteins content in diabetic training group compared to diabetic control group. Conclusion: It can be said that eight weeks of HIIT training decreased the FOXO3a/Beclin-1 autophagy pathway by decreasing FOXO3a and Beclin-1 protein content. Therefore, the use of HIIT exercises may be useful for diabetic subjects who are prone to diabetic cardiomyopathy.

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    • Cite

    APA: Copy

    JOKAR, MASOUD, & SHERAFATI MOGHADAM, MOHAMMAD. (2019). HIGH INTENSITY INTERVAL TRAINING INHIBITS AUTOPHAGY IN THE HEART TISSUE OF TYPE 2 DIABETIC RATS BY DECREASING THE CONTENT OF FOXO3A AND BECLIN-1 PROTEINS. JOURNAL OF DIABETES AND METABOLIC DISORDERS, 18(6 ), 292-299. SID. https://sid.ir/paper/412147/en

    Vancouver: Copy

    JOKAR MASOUD, SHERAFATI MOGHADAM MOHAMMAD. HIGH INTENSITY INTERVAL TRAINING INHIBITS AUTOPHAGY IN THE HEART TISSUE OF TYPE 2 DIABETIC RATS BY DECREASING THE CONTENT OF FOXO3A AND BECLIN-1 PROTEINS. JOURNAL OF DIABETES AND METABOLIC DISORDERS[Internet]. 2019;18(6 ):292-299. Available from: https://sid.ir/paper/412147/en

    IEEE: Copy

    MASOUD JOKAR, and MOHAMMAD SHERAFATI MOGHADAM, “HIGH INTENSITY INTERVAL TRAINING INHIBITS AUTOPHAGY IN THE HEART TISSUE OF TYPE 2 DIABETIC RATS BY DECREASING THE CONTENT OF FOXO3A AND BECLIN-1 PROTEINS,” JOURNAL OF DIABETES AND METABOLIC DISORDERS, vol. 18, no. 6 , pp. 292–299, 2019, [Online]. Available: https://sid.ir/paper/412147/en

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