مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Verion
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

video

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

sound

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Version

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View:

268
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Download:

0
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Cites:

Information Journal Paper

Title

The Effect of Exercise Training Intensity and Alpha-Lipoic Acid Supplement on IAPP Gene Expression in the Pancreas in Type 2 Diabetic

Pages

  1-12

Abstract

 Background: The formation of islet amyloid polypeptide (IAPP) have been proposed for d increased -cell Apoptosis in type 2 Diabetes. Exercise training plays a protective role against Diabetes. Alpha Lipoic Acid (ALA) is a powerful biological antioxidant. However, the role of exercise training and ALA on IAPP are not well understood. The aim of the present study was to investigate the effect of training with different intensity and Alpha Lipoic Acid supplement on pancreatic mRNA IAPP in rats with type 2 Diabetes. Methods: In this experimental study, 35 wistar rats were randomly divided into seven groups: control, diabetic (D), diabetic+ Alpha Lipoic Acid (ALA), diabetic high intensity training (HIT), diabetic moderate intensity training (MIT), Diabetes HIT+ALA (ALA+HIT), diabetic MIT +ALA (ALA+MIT). The HIT and MIT protocols was performed five days a week for six weeks. HIIT included 10 bouts of four minutes (running at 85– 90% of VO2max) and MIT 13 bouts of four minutes (running at 65– 70% of VO2max). ALA was administered orally 20 mg/kg once a day by gavage. Real-time PCR method for the relative expression of mRNA of IAPP gene were used. Results: The level of IPAA increased significantly in diabetic group compared to control (p=0. 0039). Also, level of IPAA decreased significantly in ALA (p=0. 01) and ALA+HIT diabetic group (p=0. 021). Conclusion: Diabetes is associated with increased mRNA IAPP in pancreatic -cell and HIT plus ALA can be as an effective intervention in decreasing IAPP in pancreatic -cell. in diabetics.

Cites

  • No record.

    • References

    Cite

    APA: Copy

    Fatemi, Abdollah, FARZANEH HESARI, AMIN, Abaszadeh, Hajar, & Dadban Shahamat, Mino. (2021). The Effect of Exercise Training Intensity and Alpha-Lipoic Acid Supplement on IAPP Gene Expression in the Pancreas in Type 2 Diabetic. JOURNAL OF DIABETES AND METABOLIC DISORDERS, 21(1 ), 1-12. SID. https://sid.ir/paper/413465/en

    Vancouver: Copy

    Fatemi Abdollah, FARZANEH HESARI AMIN, Abaszadeh Hajar, Dadban Shahamat Mino. The Effect of Exercise Training Intensity and Alpha-Lipoic Acid Supplement on IAPP Gene Expression in the Pancreas in Type 2 Diabetic. JOURNAL OF DIABETES AND METABOLIC DISORDERS[Internet]. 2021;21(1 ):1-12. Available from: https://sid.ir/paper/413465/en

    IEEE: Copy

    Abdollah Fatemi, AMIN FARZANEH HESARI, Hajar Abaszadeh, and Mino Dadban Shahamat, “The Effect of Exercise Training Intensity and Alpha-Lipoic Acid Supplement on IAPP Gene Expression in the Pancreas in Type 2 Diabetic,” JOURNAL OF DIABETES AND METABOLIC DISORDERS, vol. 21, no. 1 , pp. 1–12, 2021, [Online]. Available: https://sid.ir/paper/413465/en

    Related Journal Papers

  • No record.

    • Related Seminar Papers

  • No record.

    • Related Plans

  • No record.

    • Recommended Workshops






    Move to top
    telegram sharing button
    whatsapp sharing button
    linkedin sharing button
    twitter sharing button
    email sharing button
    email sharing button
    email sharing button
    sharethis sharing button