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Information Journal Paper

Title

Hydroalcoholic extraction of Hyssopus officinalis L has inhibitory effect on seizure progression in chemical kindling induced by PTZ

Pages

  9-16

Abstract

 Background and Objective: Epilepsy is one of the most neurological disease. Despite existence of synthetics drugs for epilepsy, some patients suffer from side effects of available medicine and its drug resistance seizures. Use of traditional herbal medicine for treatment of disease is proposed as a therapeutic modality. In attention to components of Hyssopus officinalis L.and use of it in folk medicine, the aim of this investigation was to study of the anti-convulsive effects of Hyssopus officinalis L.extract on seizure development. Material and methods: In this experimental study 56 adult male mice divided into 7 groups (n=8) including: 1-kindel group receiving only Pentylenetetrazole (PTZ) at every 48 hours (45 mg/kg of body weight), until animal show stage 5 seizure 3 – 5 times. Control group that only receiving salin. 4 experimental groups that 30 minutes before PTZ injection received hyssopus by gavages in doses of 100, 200, 400 and 800 mg/kg of body weight and in addition to, positive control group animals, received diazepam by intraperitoneal injection in doses of 2 mg/kg. Results: Data analysis indicated that treatment with hyssopus has a significant effect on chemical kindling process that comparable with diazepam. It decreases progress of seizure behavioral stages considerably (P˂ 0. 05) and increases latency time of seizure significantly (P˂ 0. 05) but don’ t has significant effect on seizure duration. Conclusion: The results shows extract of Hyssopus officinalis L.has anticonvulsant effect on PTZ kindling process. Thus, it may to be beneficial for seizure treatment

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    APA: Copy

    Changaei, Hossein, & Namvar Aghdash, Simin. (2020). Hydroalcoholic extraction of Hyssopus officinalis L has inhibitory effect on seizure progression in chemical kindling induced by PTZ. PATHOBIOLOGY RESEARCH (MODARES JOURNAL OF MEDICAL SCIENCES), 23(4 ), 9-16. SID. https://sid.ir/paper/412451/en

    Vancouver: Copy

    Changaei Hossein, Namvar Aghdash Simin. Hydroalcoholic extraction of Hyssopus officinalis L has inhibitory effect on seizure progression in chemical kindling induced by PTZ. PATHOBIOLOGY RESEARCH (MODARES JOURNAL OF MEDICAL SCIENCES)[Internet]. 2020;23(4 ):9-16. Available from: https://sid.ir/paper/412451/en

    IEEE: Copy

    Hossein Changaei, and Simin Namvar Aghdash, “Hydroalcoholic extraction of Hyssopus officinalis L has inhibitory effect on seizure progression in chemical kindling induced by PTZ,” PATHOBIOLOGY RESEARCH (MODARES JOURNAL OF MEDICAL SCIENCES), vol. 23, no. 4 , pp. 9–16, 2020, [Online]. Available: https://sid.ir/paper/412451/en

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