The effects of 8 weeks aerobic training on HIF-1α , miR-21 and VEGF gene expression in female Balb/c with breast cancer

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SOLTANI R.; KORDI M.; GAEINI A.; NURI R.

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Journal: Yafteh Year:2019 | Volume:21 | Issue:1 (79) Page(s): 63-74

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Title

The effects of 8 weeks aerobic training on HIF-1α , miR-21 and VEGF gene expression in female Balb/c with breast cancer

Author(s)

SOLTANI R. | KORDI M. | GAEINI A. | NURI R. | Issue Writer Certificate

Keywords

AngiogenesisQ2

Breast CancerQ2

Aerobic trainingQ1

HIF-1αQ1

miR-21Q1

VEGFQ1

Abstract

Background: Breast Cancer, which is a major cancer for women, affects the Angiogenesis process. Exercise training can decrease the process of Angiogenesis in tumor tissue. The aim of present study was to investigate the effects of 8 weeks of Aerobic training on HIF-1α , miR-21 and VEGF gene expression in female Balb/c mice with Breast Cancer. Materials and Methods: 16 female Balb/c mice (age: 3-5 weeks and weight: 17/1 ± 0. 1 g) were selected and randomly divided into two groups: Aerobic training and control. The Aerobic training involved running with intensity of 14-20 m/min for 5 sessions per week over 8 weeks. The gene expression of HIF-1α , miR-21 and VEGF was examined by RT&PCR. The repeated measurement ANOVA, Bonferroni post hoc test and the independent T-test were used to analyse the data, with a significant level set at p<0. 05. Results: The results showed that Aerobic training induced significant differences in the growth of tumor volume and an increase in HIF-1α . In addition, Aerobic training caused a significant decrease in the gene expression of miR-21, whereas the changes in gene expression of VEGF were not significant. Conclusion: It appears that Aerobic training caused a reduction in the gene expression of miR-21 and VEGF, which in turn, induced a decrease in the tumor volume and a corresponding improvement in the cancer.

Cites

The Effect of Endurance Training in Combination with Curcumin on Intratumoral Gene Expression of AngiomiR-126 and Angiopoietin-1 in Female Mice with Breast Cancer

References

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APA: Copy

SOLTANI, R., KORDI, M., GAEINI, A., & NURI, R.. (2019). The effects of 8 weeks aerobic training on HIF-1α , miR-21 and VEGF gene expression in female Balb/c with breast cancer. YAFTEH, 21(1 (79) ), 63-74. SID. https://sid.ir/paper/79958/en

Vancouver: Copy

SOLTANI R., KORDI M., GAEINI A., NURI R.. The effects of 8 weeks aerobic training on HIF-1α , miR-21 and VEGF gene expression in female Balb/c with breast cancer. YAFTEH[Internet]. 2019;21(1 (79) ):63-74. Available from: https://sid.ir/paper/79958/en

IEEE: Copy

R. SOLTANI, M. KORDI, A. GAEINI, and R. NURI, “The effects of 8 weeks aerobic training on HIF-1α , miR-21 and VEGF gene expression in female Balb/c with breast cancer,” YAFTEH, vol. 21, no. 1 (79) , pp. 63–74, 2019, [Online]. Available: https://sid.ir/paper/79958/en

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