EVALUATION OF DNA CONTENT (PLOIDY) INACUTE LYMPHOBLASTIC LEUKEMIA (ALL) PATIENTS BY FLOWCYTOMETRY

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SHAHIDI M.; RAKHSHAN M.; FARHADI M.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Journal: Research in Medicine Year:2003 | Volume:26 | Issue:4 Page(s): 291-294

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Title

EVALUATION OF DNA CONTENT (PLOIDY) INACUTE LYMPHOBLASTIC LEUKEMIA (ALL) PATIENTS BY FLOWCYTOMETRY

Author(s)

SHAHIDI M. | RAKHSHAN M. | FARHADI M. | Issue Writer Certificate

Keywords

FLOWCYTOMETRYQ3

DNA CONTENTQ3

ACUTE LYMPHOBLASTIC LEUKEMIAQ4

Abstract

Background: The measurement of DNA CONTENT or ploidy has become a useful tool for diagnosis and treatment of malignancies. The purpose of this study was to assess the incidence of DNA aneuploidy in children with ACUTE LYMPHOBLASTIC LEUKEMIA (ALL) and the relationship between aneuploidy and morphological subclass, immunological phenotype, leukocyte count, age, and sex.Materials and methods: DNA CONTENT and laboratory features were determined in 60 ALL patients, all of whom, were under 15 years old and have not received any treatment. DNA CONTENT was evaluated using FLOWCYTOMETRY.Results: Diploidy, hyperdiploidy, and hypodiploidy were reported in 50, 45, and 5% of patients, respectively. The mean DNA index was 1.21. We have found hyperdiploidy to be associated with lower leukocyte count (p<0.05).Conclusion: Prior investigators have not reported significant results, but mean age of hyperdiploid patients was lower than the diploid, meanwhile, early pre-B phenotype and L1 morphology among hyperdiploid patients were more common. Thus, Evaluation of DNA CONTENT can be useful and prognostic in ALL patients.

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APA: Copy

SHAHIDI, M., RAKHSHAN, M., & FARHADI, M.. (2003). EVALUATION OF DNA CONTENT (PLOIDY) INACUTE LYMPHOBLASTIC LEUKEMIA (ALL) PATIENTS BY FLOWCYTOMETRY. PAJOUHESH DAR PEZESHKI, 26(4), 291-294. SID. https://sid.ir/paper/41629/en

Vancouver: Copy

SHAHIDI M., RAKHSHAN M., FARHADI M.. EVALUATION OF DNA CONTENT (PLOIDY) INACUTE LYMPHOBLASTIC LEUKEMIA (ALL) PATIENTS BY FLOWCYTOMETRY. PAJOUHESH DAR PEZESHKI[Internet]. 2003;26(4):291-294. Available from: https://sid.ir/paper/41629/en

IEEE: Copy

M. SHAHIDI, M. RAKHSHAN, and M. FARHADI, “EVALUATION OF DNA CONTENT (PLOIDY) INACUTE LYMPHOBLASTIC LEUKEMIA (ALL) PATIENTS BY FLOWCYTOMETRY,” PAJOUHESH DAR PEZESHKI, vol. 26, no. 4, pp. 291–294, 2003, [Online]. Available: https://sid.ir/paper/41629/en

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