THCYTOTOXIC EFFECTS OF DIFFERENT CONCENTRATIONS OF SCROPHULARIA STRIATA EXTRACT ON HUMAN COLORECTAL CANCER CELLS (HT29)

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BIGDELI RAZIEH; Baghbani Arani Fahimeh; AHANGARI COHAN REZA

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Journal: Research in Medicine Year:2017 | Volume:41 | Issue:3 Page(s): 160-165

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Title

THCYTOTOXIC EFFECTS OF DIFFERENT CONCENTRATIONS OF SCROPHULARIA STRIATA EXTRACT ON HUMAN COLORECTAL CANCER CELLS (HT29)

Author(s)

BIGDELI RAZIEH | Baghbani Arani Fahimeh | AHANGARI COHAN REZA | Issue Writer Certificate

Keywords

ANTICANCER EFFECTQ1

COLORECTAL CANCERQ1

SCROPHULARIA STRIATAQ1

MTT ASSAYQ1

Abstract

Backgrond: Todays, there are considerable efforts to find plant substances as new drugs in cancer therapy. SCROPHULARIA STRIATA plants are a well-known in traditional medicine in Iran. This prompted us to investigate the antitumor effects of SCROPHULARIA STRIATA (an Iranian species) extract on human COLORECTAL CANCER (HT29) and normal (HEK 293) cell lines.Materials and Methods: In this experimental study, an extract of SCROPHULARIA STRIATA was prepared by maceration method. Then, the cytotoxicity effect of different concentrations of the SCROPHULARIA STRIATA extract was an analysis by MTT ASSAY on HT29 and HEK293 cells and IC50 for extracts was determined. Statistical analysis was done using SPSS software. The resulting data were analyzed using ANOVA test.Findings: Results of this study showed a significant cytotoxicity activity of SCROPHULARIA STRIATA extract against HT29 cells in a dose-dependent manner. So, SCROPHULARIA STRIATA extract at a concentration of 10 mg/ml to 0.1 mg/ml have toxic effects on the HT29 cells (p<0.05). However, this extract doesn’t have any cytotoxic effect on normal cells. Conclusion: The SCROPHULARIA STRIATA extract has toxic effects on tumor HT29 cell line, so it can be used as an anticancer drug with specific concentration and low side-effects.

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References

NEUROPROTECTIVE EFFECT OF TOTAL AND SEQUENTIAL EXTRACT OF SCROPHULARIA STRIATA BOISS. IN RAT CEREBELLAR GRANULE NEURONS FOLLOWING GLUTAMATE- INDUCED NEUROTOXICITY: AN IN-VITRO STUDY

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APA: Copy

BIGDELI, RAZIEH, Baghbani Arani, Fahimeh, & AHANGARI COHAN, REZA. (2017). THCYTOTOXIC EFFECTS OF DIFFERENT CONCENTRATIONS OF SCROPHULARIA STRIATA EXTRACT ON HUMAN COLORECTAL CANCER CELLS (HT29). PAJOUHESH DAR PEZESHKI, 41(3 ), 160-165. SID. https://sid.ir/paper/42201/en

Vancouver: Copy

BIGDELI RAZIEH, Baghbani Arani Fahimeh, AHANGARI COHAN REZA. THCYTOTOXIC EFFECTS OF DIFFERENT CONCENTRATIONS OF SCROPHULARIA STRIATA EXTRACT ON HUMAN COLORECTAL CANCER CELLS (HT29). PAJOUHESH DAR PEZESHKI[Internet]. 2017;41(3 ):160-165. Available from: https://sid.ir/paper/42201/en

IEEE: Copy

RAZIEH BIGDELI, Fahimeh Baghbani Arani, and REZA AHANGARI COHAN, “THCYTOTOXIC EFFECTS OF DIFFERENT CONCENTRATIONS OF SCROPHULARIA STRIATA EXTRACT ON HUMAN COLORECTAL CANCER CELLS (HT29),” PAJOUHESH DAR PEZESHKI, vol. 41, no. 3 , pp. 160–165, 2017, [Online]. Available: https://sid.ir/paper/42201/en

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