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Information Journal Paper

Title

THE ROLE OF THE AMPA RECEPTORS OF PARAGIGANTOCELLULARIS LATERALIS NUCLEUS IN INFLAMMATORY PAIN MODULATION IN OVARIECTOMIZED FEMALE RAT

Pages

  23-37

Abstract

 Background and purpose: The paragigantocellularis lateralis nucleus (LPGi) is one of theimportant nuclei involved in the noradrenergic descending pain modulation. 17β-ESTRADIOL modulatesnociception by binding to the estrogen receptors and also by allosteric interaction with other membraneboundreceptors like the glutamate receptors. In this study, the role of AMPA RECEPTORs of the LPGinucleus was investigated in the 17β-ESTRADIOL-induced pain modulation in ovariectomized rats. Materials and methods: In this study, female Wistar rats weighing 200-270 gr were used. Toinvestigate the role of the AMPA RECEPTORs of the LPGi nucleus, in both acute and persistent painmodulation, cannulation of the LPGi nucleus was performed. Primarily, drugs were injected and 15minutes later 50 μ l of 5% formalin was injected into the rat's hind paw. Then, the paw jerking behaviorwas recorded for 60 min. Results: The results showed that intra-LPGi injection of 17β-ESTRADIOL significantly reduced thepaw jerking behavior in both phases of formalin test (P< 0. 01). Pretreatment of LPGi nucleus by AMPAreceptor antagonist (CNQX) neutralized the antinociceptive effect of 17β-ESTRADIOL on paw jerkingfrequency in both phases of formalin test (P< 0. 001), and even, the CNQX induced hyperalgesia in bothphases of paw jerking behavior. Conclusion: According to this study, intra-LPGi 17β-ESTRADIOL produces modest ANALGESIA onformalin-induced pain in ovariectomized female rats, which is probably mediated via the AMPAreceptors of this nucleus.

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    APA: Copy

    KHAKPAY, ROGHAIEH, FEYZI, HANIEH, & SHEIKHZADEH HESARI, FARZAM. (2018). THE ROLE OF THE AMPA RECEPTORS OF PARAGIGANTOCELLULARIS LATERALIS NUCLEUS IN INFLAMMATORY PAIN MODULATION IN OVARIECTOMIZED FEMALE RAT. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, 28(159 ), 23-37. SID. https://sid.ir/paper/44156/en

    Vancouver: Copy

    KHAKPAY ROGHAIEH, FEYZI HANIEH, SHEIKHZADEH HESARI FARZAM. THE ROLE OF THE AMPA RECEPTORS OF PARAGIGANTOCELLULARIS LATERALIS NUCLEUS IN INFLAMMATORY PAIN MODULATION IN OVARIECTOMIZED FEMALE RAT. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2018;28(159 ):23-37. Available from: https://sid.ir/paper/44156/en

    IEEE: Copy

    ROGHAIEH KHAKPAY, HANIEH FEYZI, and FARZAM SHEIKHZADEH HESARI, “THE ROLE OF THE AMPA RECEPTORS OF PARAGIGANTOCELLULARIS LATERALIS NUCLEUS IN INFLAMMATORY PAIN MODULATION IN OVARIECTOMIZED FEMALE RAT,” JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, vol. 28, no. 159 , pp. 23–37, 2018, [Online]. Available: https://sid.ir/paper/44156/en

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