THE ANTINOCICEPTIVE EFFECT OF 17β-ESTRADIOL IN THE PARAGIGANTOCELLULARIS LATERALIS NUCLEUS OF OVARIECTOMIZED FEMALE RATS MEDIATED BY ESTROGEN RECEPTORS

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KHAKPAY ROGHAIEH; ANSARI SANAM; KHAKPAY FATEMEH

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Journal Paper

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Journal: Journal of Arak University Medical Sciences Year:2017 | Volume:20 | Issue:8 (125) Page(s): 29-38

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Title

THE ANTINOCICEPTIVE EFFECT OF 17β-ESTRADIOL IN THE PARAGIGANTOCELLULARIS LATERALIS NUCLEUS OF OVARIECTOMIZED FEMALE RATS MEDIATED BY ESTROGEN RECEPTORS

Author(s)

KHAKPAY ROGHAIEH | ANSARI SANAM | KHAKPAY FATEMEH | Issue Writer Certificate

Keywords

ANALGESIAQ1

ESTROGEN RECEPTORQ1

OVARIECTOMYQ1

17β-ESTRADIOLQ1

Abstract

Background: Paragigantocellularis lateralis (LPGi) nucleus plays a key role in the processing of pain information related to the descending pain modulation. Also, 17b-estradiol is involved in the pain modulation. The aim of the present study was to investigate the role of ESTROGEN RECEPTORs of LPGi nucleus in the 17β-estradiol-induced pain modulation in the ovariectomized rats.Materials and Methods: In this study, the female Wistar rats (180-250 gr) were used. In order to study the role of the NMDA receptors in the 17b-estradiol-induced pain modulation in the ovariectomized rats, primarily, rats were bilaterally ovariectomized and immediately cannulation of LPGi nucleus was performed. First, drugs were injected and 15 minutes later 50 ml of 5% formalin was injected into the rat' s hind paw; and then, formalin-induced paw jerking behavior was recorded for 60 min.Results: Our results indicated that intra-LPGi injection of 17b-estradiol significantly attenuated paw jerking behavior in the both phases of formalin test. Intra-LPGi injection of ESTROGEN RECEPTOR antagonist (ICI 182, 780), had no effect on the paw jerking behavior. Pre-treatment of LPGi nucleus by ICI 182, 780 counteracted the anti-nociceptive effect of 17b-estradiol both in the acute and in the chronic phases of formalin-induced paw jerking behaviour.Conclusion: Based on the results of this study, it can be concluded that the intra-LPGi 17b-estradiol produces modest ANALGESIA on the formalin-induced inflammatory pain in the ovariectomized rats, which is probably mediated via the esterogen receptors of this nucleus.

Cites

The Role of the Estrogen Receptors of Paragigantocellularis Lateralis Nucleus in the Antinociceptive Effect of 17β-Estradiol during Proestrus Phase of Estrous Cycle of Female Rats

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APA: Copy

KHAKPAY, ROGHAIEH, ANSARI, SANAM, & KHAKPAY, FATEMEH. (2017). THE ANTINOCICEPTIVE EFFECT OF 17β-ESTRADIOL IN THE PARAGIGANTOCELLULARIS LATERALIS NUCLEUS OF OVARIECTOMIZED FEMALE RATS MEDIATED BY ESTROGEN RECEPTORS. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), 20(8 (125) ), 29-38. SID. https://sid.ir/paper/69035/en

Vancouver: Copy

KHAKPAY ROGHAIEH, ANSARI SANAM, KHAKPAY FATEMEH. THE ANTINOCICEPTIVE EFFECT OF 17β-ESTRADIOL IN THE PARAGIGANTOCELLULARIS LATERALIS NUCLEUS OF OVARIECTOMIZED FEMALE RATS MEDIATED BY ESTROGEN RECEPTORS. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ)[Internet]. 2017;20(8 (125) ):29-38. Available from: https://sid.ir/paper/69035/en

IEEE: Copy

ROGHAIEH KHAKPAY, SANAM ANSARI, and FATEMEH KHAKPAY, “THE ANTINOCICEPTIVE EFFECT OF 17β-ESTRADIOL IN THE PARAGIGANTOCELLULARIS LATERALIS NUCLEUS OF OVARIECTOMIZED FEMALE RATS MEDIATED BY ESTROGEN RECEPTORS,” ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), vol. 20, no. 8 (125) , pp. 29–38, 2017, [Online]. Available: https://sid.ir/paper/69035/en

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