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Information Journal Paper

Title

THE ROLE OF NMDA RECEPTORS OF THE PARAGIGANTOCELLULARIS LATERALIS NUCLEUS IN THE ANTINOCICEPTIVE EFFECT OF 17Β-ESTRADIOL IN OVARIECTOMIZED FEMALE RATS

Pages

  23-33

Abstract

 Background: 17 b-Estradiol modulates nociception by binding to the estrogen receptors and also by allosteric interaction with other membrane-bound receptors like the NMDA RECEPTORs. The paragigantocellularis lateralis nucleus (LPGi) is also involved in the pain modulation. In this study, the role of NMDA RECEPTORs of the LPGi nucleus has been investigated in the 17 b-estradiol-induced pain modulation in the ovariectomized rats.Materials and Methods: In this study, the female Wistar rats in the range of 200-270 gr were used. In order to study the role of the NMDA RECEPTORs in the 17 b-estradiol-induced pain modulation in the ovariectomized rats, primarily, rats were bilaterally ovariectomized and immediately cannulation of the LPGi nucleus was performed. Then, drugs were injected and 15 minutes later 50 ml of 5% formalin was injected into the rat's hind paw; and formalin-induced paw jerking behaviour was recorded for 60 min.Results: The results of the present study showed that the intra-LPGi injection of 17 b-estradiol significantly reduced the paw jerking behavior both in the first and in the second phases of FORMALIN TEST. Pretreatment of the LPGi nucleus by NMDA RECEPTOR antagonist (AP5) neutralized the antinociceptive effect of 17 b-estradiol on the paw jerking frequency in the both phases of FORMALIN TEST; and induced hyperalgesia in the both phases of this behavior.Conclusion: These results indicated that the intra-LPGi injection of 17 b-estradiol produces modest ANALGESIA on the formalin-induced inflammatory pain. Therefore, it can be concluded that the NMDA RECEPTORs of the paragigantocellularis lateralis nucleus are probably involved in the antinociceptive effect of 17b-estradiol in the ovariectomized rats.

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    APA: Copy

    KHAKPAY, ROGHAIEH, FEIZY, HANIEH, & SHEIKHZADEH HESARI, FARZAM. (2017). THE ROLE OF NMDA RECEPTORS OF THE PARAGIGANTOCELLULARIS LATERALIS NUCLEUS IN THE ANTINOCICEPTIVE EFFECT OF 17?-ESTRADIOL IN OVARIECTOMIZED FEMALE RATS. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), 20(7 (124)), 23-33. SID. https://sid.ir/paper/69718/en

    Vancouver: Copy

    KHAKPAY ROGHAIEH, FEIZY HANIEH, SHEIKHZADEH HESARI FARZAM. THE ROLE OF NMDA RECEPTORS OF THE PARAGIGANTOCELLULARIS LATERALIS NUCLEUS IN THE ANTINOCICEPTIVE EFFECT OF 17?-ESTRADIOL IN OVARIECTOMIZED FEMALE RATS. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ)[Internet]. 2017;20(7 (124)):23-33. Available from: https://sid.ir/paper/69718/en

    IEEE: Copy

    ROGHAIEH KHAKPAY, HANIEH FEIZY, and FARZAM SHEIKHZADEH HESARI, “THE ROLE OF NMDA RECEPTORS OF THE PARAGIGANTOCELLULARIS LATERALIS NUCLEUS IN THE ANTINOCICEPTIVE EFFECT OF 17?-ESTRADIOL IN OVARIECTOMIZED FEMALE RATS,” ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), vol. 20, no. 7 (124), pp. 23–33, 2017, [Online]. Available: https://sid.ir/paper/69718/en

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