IMPACT OF EXTRACTION METHODS ON TOTAL PHENOLIC AND FLAVONOID CONTENTS, ANTIOXIDANT AND ANTIHYPOXIC PROPERTIES OF ALLIUM AMPELOPRASUM IN MICE

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SHAHNAZI RAZIEH; MEHRDADFAR FARIBORZ; EBRAHIMZADEH MOHAMMAD ALI

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Journal: JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES Year:2018 | Volume:27 | Issue:158 Page(s): 27-44

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Title

IMPACT OF EXTRACTION METHODS ON TOTAL PHENOLIC AND FLAVONOID CONTENTS, ANTIOXIDANT AND ANTIHYPOXIC PROPERTIES OF ALLIUM AMPELOPRASUM IN MICE

Author(s)

SHAHNAZI RAZIEH | MEHRDADFAR FARIBORZ | EBRAHIMZADEH MOHAMMAD ALI | Issue Writer Certificate

Keywords

MACERATIONQ2

SOXHLETQ1

ANTIOXIDANTQ2

TOTAL PHENOLICSQ2

TOTAL FLAVONOIDSQ2

ANTI-HYPOXIAQ1

Abstract

Background and purpose: Allium (Liliaceae) genus has about 600 spp. This investigation wasdesigned to study the impact of extraction methods on total phenolic and flavonoid contents, ANTIOXIDANT, and antihypoxic properties of A. ampeloprasum in mice. Materials and methods: The aerial parts were extracted by three different methods, i. e. MACERATION, ultrasonic assisted (UAE) and SOXHLET assisted extraction (SAE). The total phenolic andflavonoid contents were determined. Antioxidative capacity was assessed utilizing four different methods. Antihypoxic activities of MACERATION extract against hypoxia-induced lethality in haemic, asphytic andcirculatory hypoxia models. Results: SOXHLET assisted extract showed the highest amount of total phenolic contents (89. 1± 3. 3GAE) and Ultrasonic assisted extract showed the highest amount of total flavonoid contents (36. 9± 1. 7QE). In DPPH radical scavenging activity, MACERATION extract had higher activity which was significantlydifferent from that of other extracts (IC50 622. 6± 12. 7). Extraction method did not show any effect onreducing power. All extracts showed the same activity (P>0. 05). Extracts did not show any good nitricoxide radical scavenging and iron chelating activities. In haemic and asphytic models, the extract at 250mg/kg showed statistically significant activities compared with that in the controls. In circulatory modelthe extract at 500 mg/kg, significantly prolonged the latency for death compared with that in controlgroups (P<0. 05). Conclusion: According to current study, extraction methods significantly affected ANTIOXIDANTcapacities and total phenolic and flavonoid contents. For A. ampeloprasum, MACERATION extraction wasfound to be more efficient. It showed high antihypoxic properties.

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APA: Copy

SHAHNAZI, RAZIEH, MEHRDADFAR, FARIBORZ, & EBRAHIMZADEH, MOHAMMAD ALI. (2018). IMPACT OF EXTRACTION METHODS ON TOTAL PHENOLIC AND FLAVONOID CONTENTS, ANTIOXIDANT AND ANTIHYPOXIC PROPERTIES OF ALLIUM AMPELOPRASUM IN MICE. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, 27(158 ), 27-44. SID. https://sid.ir/paper/44189/en

Vancouver: Copy

SHAHNAZI RAZIEH, MEHRDADFAR FARIBORZ, EBRAHIMZADEH MOHAMMAD ALI. IMPACT OF EXTRACTION METHODS ON TOTAL PHENOLIC AND FLAVONOID CONTENTS, ANTIOXIDANT AND ANTIHYPOXIC PROPERTIES OF ALLIUM AMPELOPRASUM IN MICE. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2018;27(158 ):27-44. Available from: https://sid.ir/paper/44189/en

IEEE: Copy

RAZIEH SHAHNAZI, FARIBORZ MEHRDADFAR, and MOHAMMAD ALI EBRAHIMZADEH, “IMPACT OF EXTRACTION METHODS ON TOTAL PHENOLIC AND FLAVONOID CONTENTS, ANTIOXIDANT AND ANTIHYPOXIC PROPERTIES OF ALLIUM AMPELOPRASUM IN MICE,” JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, vol. 27, no. 158 , pp. 27–44, 2018, [Online]. Available: https://sid.ir/paper/44189/en

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